FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000983409> ?p ?o ?g. }

• W2000983409 endingPage "890" @default.
• W2000983409 startingPage "879" @default.
• W2000983409 abstract "Bone development requires the recruitment of osteoclast precursors from surrounding mesenchyme, thereby allowing the key events of bone growth such as marrow cavity formation, capillary invasion, and matrix remodeling. We demonstrate that mice deficient in gelatinase B/matrix metalloproteinase (MMP)-9 exhibit a delay in osteoclast recruitment. Histological analysis and specialized invasion and bone resorption models show that MMP-9 is specifically required for the invasion of osteoclasts and endothelial cells into the discontinuously mineralized hypertrophic cartilage that fills the core of the diaphysis. However, MMPs other than MMP-9 are required for the passage of the cells through unmineralized type I collagen of the nascent bone collar, and play a role in resorption of mineralized matrix. MMP-9 stimulates the solubilization of unmineralized cartilage by MMP-13, a collagenase highly expressed in hypertrophic cartilage before osteoclast invasion. Hypertrophic cartilage also expresses vascular endothelial growth factor (VEGF), which binds to extracellular matrix and is made bioavailable by MMP-9 (Bergers, G., R. Brekken, G. McMahon, T.H. Vu, T. Itoh, K. Tamaki, K. Tanzawa, P. Thorpe, S. Itohara, Z. Werb, and D. Hanahan. 2000. Nat. Cell Biol. 2:737–744). We show that VEGF is a chemoattractant for osteoclasts. Moreover, invasion of osteoclasts into the hypertrophic cartilage requires VEGF because it is inhibited by blocking VEGF function. These observations identify specific actions of MMP-9 and VEGF that are critical for early bone development." @default.
• W2000983409 created "2016-06-24" @default.
• W2000983409 creator A5001350750 @default.
• W2000983409 creator A5005716062 @default.
• W2000983409 creator A5022137244 @default.
• W2000983409 creator A5024152209 @default.
• W2000983409 creator A5027949083 @default.
• W2000983409 creator A5036881362 @default.
• W2000983409 creator A5048523154 @default.
• W2000983409 creator A5049717703 @default.
• W2000983409 creator A5080483383 @default.
• W2000983409 creator A5080876023 @default.
• W2000983409 creator A5082542112 @default.
• W2000983409 date "2000-11-13" @default.
• W2000983409 modified "2023-10-14" @default.
• W2000983409 title "Matrix Metalloproteinase 9 and Vascular Endothelial Growth Factor Are Essential for Osteoclast Recruitment into Developing Long Bones" @default.
• W2000983409 cites W1221968489 @default.
• W2000983409 cites W1511482991 @default.
• W2000983409 cites W1534645474 @default.
• W2000983409 cites W1562276416 @default.
• W2000983409 cites W1574172480 @default.
• W2000983409 cites W1583699618 @default.
• W2000983409 cites W1632319713 @default.
• W2000983409 cites W1657484783 @default.
• W2000983409 cites W1741255825 @default.
• W2000983409 cites W1885242166 @default.
• W2000983409 cites W1895902281 @default.
• W2000983409 cites W1903249652 @default.
• W2000983409 cites W1953148896 @default.
• W2000983409 cites W1982267750 @default.
• W2000983409 cites W1985744266 @default.
• W2000983409 cites W1988699576 @default.
• W2000983409 cites W1993064864 @default.
• W2000983409 cites W2000647744 @default.
• W2000983409 cites W2001124438 @default.
• W2000983409 cites W2001362512 @default.
• W2000983409 cites W2004985449 @default.
• W2000983409 cites W2008515312 @default.
• W2000983409 cites W2016411107 @default.
• W2000983409 cites W2016484384 @default.
• W2000983409 cites W2018370408 @default.
• W2000983409 cites W2020544906 @default.
• W2000983409 cites W2020891044 @default.
• W2000983409 cites W2024602261 @default.
• W2000983409 cites W2025062557 @default.
• W2000983409 cites W2025162592 @default.
• W2000983409 cites W2034353499 @default.
• W2000983409 cites W2040385059 @default.
• W2000983409 cites W2041138285 @default.
• W2000983409 cites W2044669548 @default.
• W2000983409 cites W2048299560 @default.
• W2000983409 cites W2058844752 @default.
• W2000983409 cites W2061480819 @default.
• W2000983409 cites W2063048904 @default.
• W2000983409 cites W2063051429 @default.
• W2000983409 cites W2064705331 @default.
• W2000983409 cites W2072513862 @default.
• W2000983409 cites W2073614902 @default.
• W2000983409 cites W2082690111 @default.
• W2000983409 cites W2084168776 @default.
• W2000983409 cites W2087419193 @default.
• W2000983409 cites W2087537408 @default.
• W2000983409 cites W2088047697 @default.
• W2000983409 cites W2091273235 @default.
• W2000983409 cites W2100282191 @default.
• W2000983409 cites W2111431607 @default.
• W2000983409 cites W2112327424 @default.
• W2000983409 cites W2112509531 @default.
• W2000983409 cites W2118837944 @default.
• W2000983409 cites W2122720369 @default.
• W2000983409 cites W2131357215 @default.
• W2000983409 cites W2148880214 @default.
• W2000983409 cites W2158630265 @default.
• W2000983409 cites W2169282371 @default.
• W2000983409 cites W2170843968 @default.
• W2000983409 cites W2172114097 @default.
• W2000983409 cites W2395794581 @default.
• W2000983409 cites W2427071766 @default.
• W2000983409 cites W246460242 @default.
• W2000983409 cites W2503323289 @default.
• W2000983409 cites W4294352168 @default.
• W2000983409 cites W71979682 @default.
• W2000983409 cites W76995127 @default.
• W2000983409 cites W999341611 @default.
• W2000983409 doi "https://doi.org/10.1083/jcb.151.4.879" @default.
• W2000983409 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2169432" @default.
• W2000983409 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11076971" @default.
• W2000983409 hasPublicationYear "2000" @default.
• W2000983409 type Work @default.
• W2000983409 sameAs 2000983409 @default.
• W2000983409 citedByCount "552" @default.
• W2000983409 countsByYear W20009834092012 @default.
• W2000983409 countsByYear W20009834092013 @default.
• W2000983409 countsByYear W20009834092014 @default.
• W2000983409 countsByYear W20009834092015 @default.
• W2000983409 countsByYear W20009834092016 @default.
• W2000983409 countsByYear W20009834092017 @default.
• W2000983409 countsByYear W20009834092018 @default.

• next