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- W2000983458 abstract "The epidemiologic approach to determining the causes of disease involves identification of potential risk factors, and then comparison of disease incidence among people with varying levels of the risk factors. In this presentation, I define risk factors which correspond to different levels of genetic and environmental proximity to index cases of birth defects. Genetic proximity is estimated by the coefficient of relationship, i.e. 0.5 for siblings and dizygotic twins, and 1.0 for monozygotic twins. Environmental proximity is measured by a combination of two dichotomous variables which reflect sharing of potentially preventable environmental risk factors: one variable for those risk factors common to siblings and the other for those common only to twins. The association between these risk factors and birth defects is estimated using a linear model of the correlation of liability for different relatives. The coefficients derived from this model reflect the relative importance of genetic and different types of environmental risk factors as causes for the defects. Information so obtained could direct further study to those birth defects most likely to be preventable." @default.
- W2000983458 created "2016-06-24" @default.
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- W2000983458 date "1985-04-01" @default.
- W2000983458 modified "2023-09-26" @default.
- W2000983458 title "568 A NEW MODEL FOR DETERMINING THE RELATIVE IMPORTANCE OF GENES AND ENVIRONMENT AS CAUSES OF BIRTH DEFECTS" @default.
- W2000983458 doi "https://doi.org/10.1203/00006450-198504000-00598" @default.
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