FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000985665> ?p ?o ?g. }

• W2000985665 endingPage "1832" @default.
• W2000985665 startingPage "1828" @default.
• W2000985665 abstract "Acid-sensing ion channel-1a (ASIC1a) is localized in brain regions with high synaptic density and is thought to contribute to synaptic plasticity, learning, and memory. A prominent hypothesis is that activation of postsynaptic ASICs promotes depolarization, thereby augmenting N-methyl-d-aspartate receptor function and contributing to the induction of long-term potentiation (LTP). However, evidence for activation of postsynaptic ASICs during neurotransmission has not been established. Here, we re-examined the role of ASIC1a in LTP in the hippocampus using pharmacological and genetic approaches. Our results showed that a tarantula peptide psalmotoxin, which profoundly blocked ASIC currents in the hippocampal neurons, had no effect on LTP. Similarly, normal LTP was robustly generated in ASIC1a-null mice. A further behavioral analysis showed that mice lacking ASIC1a had normal performance in hippocampus-dependent spatial memory. In summary, our results indicate that ASIC1a is not required for hippocampal LTP and spatial memory. We therefore propose that the role of ASIC1a in LTP and spatial learning should be reassessed." @default.
• W2000985665 created "2016-06-24" @default.
• W2000985665 creator A5004218442 @default.
• W2000985665 creator A5009744334 @default.
• W2000985665 creator A5014611690 @default.
• W2000985665 creator A5024143943 @default.
• W2000985665 creator A5025215696 @default.
• W2000985665 creator A5049160395 @default.
• W2000985665 creator A5050885832 @default.
• W2000985665 creator A5076809442 @default.
• W2000985665 creator A5089117587 @default.
• W2000985665 date "2013-01-30" @default.
• W2000985665 modified "2023-10-14" @default.
• W2000985665 title "Acid-Sensing Ion Channel-1a Is Not Required for Normal Hippocampal LTP and Spatial Memory" @default.
• W2000985665 cites W1522621248 @default.
• W2000985665 cites W1761323037 @default.
• W2000985665 cites W1827209814 @default.
• W2000985665 cites W1965498307 @default.
• W2000985665 cites W1974642350 @default.
• W2000985665 cites W1989289789 @default.
• W2000985665 cites W1998564418 @default.
• W2000985665 cites W2001567401 @default.
• W2000985665 cites W2003077765 @default.
• W2000985665 cites W2013408012 @default.
• W2000985665 cites W2013711061 @default.
• W2000985665 cites W2016772559 @default.
• W2000985665 cites W2017169966 @default.
• W2000985665 cites W2019601077 @default.
• W2000985665 cites W2036902033 @default.
• W2000985665 cites W2037341321 @default.
• W2000985665 cites W2045431172 @default.
• W2000985665 cites W2046696653 @default.
• W2000985665 cites W2066442803 @default.
• W2000985665 cites W2070961029 @default.
• W2000985665 cites W2093896324 @default.
• W2000985665 cites W2095419398 @default.
• W2000985665 cites W2141911467 @default.
• W2000985665 cites W2157349006 @default.
• W2000985665 cites W2165810797 @default.
• W2000985665 doi "https://doi.org/10.1523/jneurosci.4132-12.2013" @default.
• W2000985665 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6619135" @default.
• W2000985665 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23365222" @default.
• W2000985665 hasPublicationYear "2013" @default.
• W2000985665 type Work @default.
• W2000985665 sameAs 2000985665 @default.
• W2000985665 citedByCount "53" @default.
• W2000985665 countsByYear W20009856652013 @default.
• W2000985665 countsByYear W20009856652014 @default.
• W2000985665 countsByYear W20009856652015 @default.
• W2000985665 countsByYear W20009856652016 @default.
• W2000985665 countsByYear W20009856652017 @default.
• W2000985665 countsByYear W20009856652018 @default.
• W2000985665 countsByYear W20009856652019 @default.
• W2000985665 countsByYear W20009856652020 @default.
• W2000985665 countsByYear W20009856652021 @default.
• W2000985665 countsByYear W20009856652022 @default.
• W2000985665 countsByYear W20009856652023 @default.
• W2000985665 crossrefType "journal-article" @default.
• W2000985665 hasAuthorship W2000985665A5004218442 @default.
• W2000985665 hasAuthorship W2000985665A5009744334 @default.
• W2000985665 hasAuthorship W2000985665A5014611690 @default.
• W2000985665 hasAuthorship W2000985665A5024143943 @default.
• W2000985665 hasAuthorship W2000985665A5025215696 @default.
• W2000985665 hasAuthorship W2000985665A5049160395 @default.
• W2000985665 hasAuthorship W2000985665A5050885832 @default.
• W2000985665 hasAuthorship W2000985665A5076809442 @default.
• W2000985665 hasAuthorship W2000985665A5089117587 @default.
• W2000985665 hasBestOaLocation W20009856651 @default.
• W2000985665 hasConcept C143928317 @default.
• W2000985665 hasConcept C148762608 @default.
• W2000985665 hasConcept C169760540 @default.
• W2000985665 hasConcept C170493617 @default.
• W2000985665 hasConcept C185592680 @default.
• W2000985665 hasConcept C197341189 @default.
• W2000985665 hasConcept C200170125 @default.
• W2000985665 hasConcept C25274449 @default.
• W2000985665 hasConcept C2781161787 @default.
• W2000985665 hasConcept C50254741 @default.
• W2000985665 hasConcept C55493867 @default.
• W2000985665 hasConcept C86803240 @default.
• W2000985665 hasConcept C98229152 @default.
• W2000985665 hasConceptScore W2000985665C143928317 @default.
• W2000985665 hasConceptScore W2000985665C148762608 @default.
• W2000985665 hasConceptScore W2000985665C169760540 @default.
• W2000985665 hasConceptScore W2000985665C170493617 @default.
• W2000985665 hasConceptScore W2000985665C185592680 @default.
• W2000985665 hasConceptScore W2000985665C197341189 @default.
• W2000985665 hasConceptScore W2000985665C200170125 @default.
• W2000985665 hasConceptScore W2000985665C25274449 @default.
• W2000985665 hasConceptScore W2000985665C2781161787 @default.
• W2000985665 hasConceptScore W2000985665C50254741 @default.
• W2000985665 hasConceptScore W2000985665C55493867 @default.
• W2000985665 hasConceptScore W2000985665C86803240 @default.
• W2000985665 hasConceptScore W2000985665C98229152 @default.
• W2000985665 hasIssue "5" @default.
• W2000985665 hasLocation W20009856651 @default.
• W2000985665 hasLocation W20009856652 @default.
• W2000985665 hasLocation W20009856653 @default.

• next