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- W2000986354 abstract "A bridging chemistry process was developed to form an ether bridge between 6-O and 11-O of erythromycin A via a tandem or stepwise palladium-catalyzed bis-pi-allylation. By applying this bridging process, new 6,11-O-bridged bicyclic ketolides (BBKs) were synthesized. These BBKs showed good antibacterial activities against the macrolide-susceptible strains as well as mef-resistant strains and served as a good core for further modifications to study the structure-activity relationship (SAR) and to overcome bacterial resistance. [reaction: see text]" @default.
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- W2000986354 date "2005-04-05" @default.
- W2000986354 modified "2023-09-24" @default.
- W2000986354 title "Synthesis of Novel 6,11-O-Bridged Bicyclic Ketolides via a Palladium-Catalyzed Bis-allylation." @default.
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- W2000986354 doi "https://doi.org/10.1002/chin.200514214" @default.
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