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• W2000986606 abstract "The pharmacological modulatory effects of 20(S)‑ginsenoside Rg3 (20S‑Rg3) on multidrug resistant cancer cells are reported in the present study. The effects of 20(S)‑Rg3 on the modulation of doxorubicin (DOX) and vincristine (VCR) resistance were examined in the HL60 multidrug resistant subline of human acute myeloid leukemia cells. Results demonstrated that 20S‑Rg3 is as effective as verapamil (Vp) for modulating the high degree primary DOX resistance and low degree VCR cross‑resistance expressed by the H160 cell line. Furthermore, the present study demonstrates for the first time, using isobologram analysis, that the combination of 20S‑Rg3 and Vp enhances the reversal of DOX and VCR resistance in a supra‑additive or at least an additive manner. These results indicate that 20S‑Rg3 may be used as a Vp synergizer or as a promising alternative to Vp in the chemosensitization of multidrug resistant acute myeloid leukemia, with far fewer side effects." @default.
• W2000986606 created "2016-06-24" @default.
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• W2000986606 date "2014-01-24" @default.
• W2000986606 modified "2023-10-03" @default.
• W2000986606 title "Synergistic effect of ginsenoside Rg3 with verapamil on the modulation of multidrug resistance in human acute myeloid leukemia cells" @default.
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• W2000986606 doi "https://doi.org/10.3892/ol.2014.1826" @default.
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