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• W2000987082 abstract "Feeding a marginally low iron content (18–20 mg/kg) experimental diet for 8 weeks to a group of young weaned rats (3-week old) did not alter the packed cell volume and hemoglobin. However, a significant reduction was observed in non-heme iron contents of brain (17%, p<0.01) and liver (68%, p<0.001) of experimental animals compared to their values in control rats receiving 390 mg iron/kg diet. Lower levels of tyrosine in whole brain (17%, p<0.05), corpus striatum region of brain (21%, p<0.05), and liver (22%, p<0.01) and that of dopamine (19%, p<0.01) and homovanillic acid (22%, p<0.01) in corpus striatum region were found in iron-deficient animals compared to controls. The activity of tyrosine aminotransferase increased in liver (26%, p<0.05) and corpus striatum (15%, p<0.02), however, striatal monoamine oxidase activity was found to be decreased (23%, p<0.05). The observed alterations in hepatic tyrosine metabolism may have some influence on the level of this amino acid, precursor of dopamine synthesis, in the central nervous system of iron-deficient rats. The low iron diet did not affect the levels of protein, DNA, norepinephrine and monoamine oxidase activity significantly in whole brain. Furthermore, the body and organ (brain and liver) weights of the rats of the two groups did not differ significantly during the experiment. Rehabilitation of 8-week iron-deficient rats with iron sufficient diet (390 mg iron/kg) for 2 weeks showed a complete recovery of tyrosine content and tyrosine aminotransferase activities in liver and monoamine oxidase and tyrosine aminotransferase activities in corpus striatum, but no significant alterations were observed in other parameters. Rehabilitation did not produce any appreciable effect on depressed brain non-heme iron. However, a significant improvement in the hepatic non-heme iron was noticed. It may be concluded that latent iron deficiency altered the metabolism of striatal dopamine which could not be recovered after two weeks of rehabilitation with iron-sufficient diet." @default.
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• W2000987082 date "1989-10-01" @default.
• W2000987082 modified "2023-09-26" @default.
• W2000987082 title "Studies on brain catecholamine metabolism following latent iron deficiency and subsequent rehabilitation in rat" @default.
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• W2000987082 doi "https://doi.org/10.1016/s0271-5317(89)80053-3" @default.
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