FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000988086> ?p ?o ?g. }

• W2000988086 endingPage "3996" @default.
• W2000988086 startingPage "3990" @default.
• W2000988086 abstract "The use of avian herpesviruses (Marek's disease virus, MDV) as vectors to express the capsid protein of infectious bursal disease virus (IBDV) was well established, and its protection against IBDV challenge has been evaluated previously. However, there is little data about rMDV1 expressing the VP2 protein of IBDV protecting SPF and commercial chickens against virulent IBDV (vIBDV) challenge. In this study, we constructed a stable rMDV1 expressing the VP2 protein of IBDV by inserting the coding sequence within the US10 gene of MDVl by homologous recombination and designated this as rMDVl-US10L, and evaluated effectiveness of the recombinant VP2 protein with SPF chickens and commercial chickens with maternal antibodies in vIBDV challenge. The results can be summarized as follows: (1) We constructed a rMDV1 expressing IBDV-VP2 under the control of the MDV1 glycoprotein B (gB) promoter [rMDV1-US10L]. (2) rMDV-VP2 protein was readily expressed and induced 53% protection against a vIBDV challenge in SPF chickens with 10(3)PFU/chicken, whereas 10(4)PFU induced 73% protection. (3) Vaccination of commercial chickens having maternal antibodies to rMDV1-VP2 induced 87% protection in vIBDV challenge, which was similar to results using the live vaccine, BJ87 IBDV strain, in commercial chickens. These results demonstrate that the VP2 antigen expressed in the MDV vector was an effective and stable vaccine in correlation with the vaccine efficacy against lethal IBDV challenge, and can provide a better protective effect that is likely to persist for the life of the chickens." @default.
• W2000988086 created "2016-06-24" @default.
• W2000988086 creator A5007026874 @default.
• W2000988086 creator A5029553601 @default.
• W2000988086 creator A5048080833 @default.
• W2000988086 creator A5050655777 @default.
• W2000988086 creator A5054859377 @default.
• W2000988086 creator A5069879150 @default.
• W2000988086 date "2010-05-01" @default.
• W2000988086 modified "2023-09-29" @default.
• W2000988086 title "Protection of chickens, with or without maternal antibodies, against IBDV infection by a recombinant IBDV-VP2 protein" @default.
• W2000988086 cites W1487296743 @default.
• W2000988086 cites W1628781333 @default.
• W2000988086 cites W1964009966 @default.
• W2000988086 cites W1976307282 @default.
• W2000988086 cites W1981075470 @default.
• W2000988086 cites W1990930359 @default.
• W2000988086 cites W1993730532 @default.
• W2000988086 cites W1998087925 @default.
• W2000988086 cites W2006287959 @default.
• W2000988086 cites W2015961728 @default.
• W2000988086 cites W2019602944 @default.
• W2000988086 cites W2031432943 @default.
• W2000988086 cites W2031912402 @default.
• W2000988086 cites W2044035465 @default.
• W2000988086 cites W2048994713 @default.
• W2000988086 cites W2052612096 @default.
• W2000988086 cites W2059326928 @default.
• W2000988086 cites W2059494914 @default.
• W2000988086 cites W2084915267 @default.
• W2000988086 cites W2100837269 @default.
• W2000988086 cites W2102053035 @default.
• W2000988086 cites W2109326893 @default.
• W2000988086 cites W2109739804 @default.
• W2000988086 cites W2111965996 @default.
• W2000988086 cites W2128793386 @default.
• W2000988086 cites W2144679271 @default.
• W2000988086 cites W2158407000 @default.
• W2000988086 cites W2158758215 @default.
• W2000988086 cites W2313648152 @default.
• W2000988086 cites W2316461908 @default.
• W2000988086 cites W2316592224 @default.
• W2000988086 doi "https://doi.org/10.1016/j.vaccine.2010.03.021" @default.
• W2000988086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20338216" @default.
• W2000988086 hasPublicationYear "2010" @default.
• W2000988086 type Work @default.
• W2000988086 sameAs 2000988086 @default.
• W2000988086 citedByCount "33" @default.
• W2000988086 countsByYear W20009880862012 @default.
• W2000988086 countsByYear W20009880862013 @default.
• W2000988086 countsByYear W20009880862014 @default.
• W2000988086 countsByYear W20009880862015 @default.
• W2000988086 countsByYear W20009880862016 @default.
• W2000988086 countsByYear W20009880862017 @default.
• W2000988086 countsByYear W20009880862018 @default.
• W2000988086 countsByYear W20009880862020 @default.
• W2000988086 countsByYear W20009880862021 @default.
• W2000988086 countsByYear W20009880862022 @default.
• W2000988086 countsByYear W20009880862023 @default.
• W2000988086 crossrefType "journal-article" @default.
• W2000988086 hasAuthorship W2000988086A5007026874 @default.
• W2000988086 hasAuthorship W2000988086A5029553601 @default.
• W2000988086 hasAuthorship W2000988086A5048080833 @default.
• W2000988086 hasAuthorship W2000988086A5050655777 @default.
• W2000988086 hasAuthorship W2000988086A5054859377 @default.
• W2000988086 hasAuthorship W2000988086A5069879150 @default.
• W2000988086 hasConcept C104317684 @default.
• W2000988086 hasConcept C159047783 @default.
• W2000988086 hasConcept C159654299 @default.
• W2000988086 hasConcept C202878990 @default.
• W2000988086 hasConcept C203014093 @default.
• W2000988086 hasConcept C22070199 @default.
• W2000988086 hasConcept C2522874641 @default.
• W2000988086 hasConcept C2777810641 @default.
• W2000988086 hasConcept C40767141 @default.
• W2000988086 hasConcept C55493867 @default.
• W2000988086 hasConcept C60987743 @default.
• W2000988086 hasConcept C86803240 @default.
• W2000988086 hasConcept C89423630 @default.
• W2000988086 hasConceptScore W2000988086C104317684 @default.
• W2000988086 hasConceptScore W2000988086C159047783 @default.
• W2000988086 hasConceptScore W2000988086C159654299 @default.
• W2000988086 hasConceptScore W2000988086C202878990 @default.
• W2000988086 hasConceptScore W2000988086C203014093 @default.
• W2000988086 hasConceptScore W2000988086C22070199 @default.
• W2000988086 hasConceptScore W2000988086C2522874641 @default.
• W2000988086 hasConceptScore W2000988086C2777810641 @default.
• W2000988086 hasConceptScore W2000988086C40767141 @default.
• W2000988086 hasConceptScore W2000988086C55493867 @default.
• W2000988086 hasConceptScore W2000988086C60987743 @default.
• W2000988086 hasConceptScore W2000988086C86803240 @default.
• W2000988086 hasConceptScore W2000988086C89423630 @default.
• W2000988086 hasIssue "23" @default.
• W2000988086 hasLocation W20009880861 @default.
• W2000988086 hasLocation W20009880862 @default.
• W2000988086 hasOpenAccess W2000988086 @default.
• W2000988086 hasPrimaryLocation W20009880861 @default.
• W2000988086 hasRelatedWork W1965597722 @default.

• next