Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000988854> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2000988854 endingPage "676" @default.
- W2000988854 startingPage "669" @default.
- W2000988854 abstract "A number of metabolites of the anticonvulsant drug valproic acid (VPA) as well as related substances were tested in regard to their teratogenicity in the mouse following single sc injections of 600 mg/kg on Day 8 of gestation. VPA was highly teratogenic at this dose level and over 60% of live fetuses had neural tube defects (exencephaly). Homologous compounds with shorter or longer alkyl chains were less teratogenic. Substitution of the α-H atoms in related branched carboxylic acids by methyl or ethyl groups abolished the teratogenic response. Introduction of a double bond in the ω-position of VPA (4-en-VPA) did not change the teratogenicity of VPA, while a ω-2 double bond (2-en-VPA) abolished teratogenicity. The other VPA metabolites tested as well as two straight-chain acids (n-octanoic acid and 4-pentenoic acid) and the two clinically used substances valpromide (valproic acid amide) and ethosuximide did not induce neural tube defects, although some of them induced slightly increased resorption rates and fetal weight retardation. The serum protein binding capacities of the various compounds did not correlate with the teratogenic response. Also the concentrations reached in the gestational material did not predict the teratogenicity of the substances tested. Our results indicate that the teratogenicity of the class of compounds studied represents a more specific effect than the anticonvulsant activity which could lead to the development of alternative antiepileptic drugs with low embryotoxic potential." @default.
- W2000988854 created "2016-06-24" @default.
- W2000988854 creator A5010235451 @default.
- W2000988854 creator A5026995646 @default.
- W2000988854 date "1986-05-01" @default.
- W2000988854 modified "2023-10-18" @default.
- W2000988854 title "Pharmacologic evaluation of various metabolites and analogs of valproic acid: Teratogenic potencies in mice" @default.
- W2000988854 cites W1810449496 @default.
- W2000988854 cites W1983334633 @default.
- W2000988854 cites W1986204130 @default.
- W2000988854 cites W1996491075 @default.
- W2000988854 cites W1999214964 @default.
- W2000988854 cites W2001074356 @default.
- W2000988854 cites W2001404673 @default.
- W2000988854 cites W2048316263 @default.
- W2000988854 cites W2051630317 @default.
- W2000988854 cites W2055517568 @default.
- W2000988854 cites W2092412436 @default.
- W2000988854 cites W2154346953 @default.
- W2000988854 cites W2154675119 @default.
- W2000988854 cites W2162207335 @default.
- W2000988854 cites W2334212809 @default.
- W2000988854 cites W2412380707 @default.
- W2000988854 doi "https://doi.org/10.1016/0272-0590(86)90180-6" @default.
- W2000988854 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3086174" @default.
- W2000988854 hasPublicationYear "1986" @default.
- W2000988854 type Work @default.
- W2000988854 sameAs 2000988854 @default.
- W2000988854 citedByCount "133" @default.
- W2000988854 countsByYear W20009888542012 @default.
- W2000988854 countsByYear W20009888542013 @default.
- W2000988854 countsByYear W20009888542014 @default.
- W2000988854 countsByYear W20009888542015 @default.
- W2000988854 countsByYear W20009888542016 @default.
- W2000988854 countsByYear W20009888542017 @default.
- W2000988854 countsByYear W20009888542018 @default.
- W2000988854 countsByYear W20009888542020 @default.
- W2000988854 countsByYear W20009888542021 @default.
- W2000988854 countsByYear W20009888542022 @default.
- W2000988854 countsByYear W20009888542023 @default.
- W2000988854 crossrefType "journal-article" @default.
- W2000988854 hasAuthorship W2000988854A5010235451 @default.
- W2000988854 hasAuthorship W2000988854A5026995646 @default.
- W2000988854 hasConcept C118552586 @default.
- W2000988854 hasConcept C172680121 @default.
- W2000988854 hasConcept C185592680 @default.
- W2000988854 hasConcept C196843134 @default.
- W2000988854 hasConcept C2775858608 @default.
- W2000988854 hasConcept C2777172819 @default.
- W2000988854 hasConcept C2778186239 @default.
- W2000988854 hasConcept C2779234561 @default.
- W2000988854 hasConcept C2780594696 @default.
- W2000988854 hasConcept C2781052626 @default.
- W2000988854 hasConcept C54355233 @default.
- W2000988854 hasConcept C65290608 @default.
- W2000988854 hasConcept C71924100 @default.
- W2000988854 hasConcept C86803240 @default.
- W2000988854 hasConcept C95444343 @default.
- W2000988854 hasConcept C98274493 @default.
- W2000988854 hasConceptScore W2000988854C118552586 @default.
- W2000988854 hasConceptScore W2000988854C172680121 @default.
- W2000988854 hasConceptScore W2000988854C185592680 @default.
- W2000988854 hasConceptScore W2000988854C196843134 @default.
- W2000988854 hasConceptScore W2000988854C2775858608 @default.
- W2000988854 hasConceptScore W2000988854C2777172819 @default.
- W2000988854 hasConceptScore W2000988854C2778186239 @default.
- W2000988854 hasConceptScore W2000988854C2779234561 @default.
- W2000988854 hasConceptScore W2000988854C2780594696 @default.
- W2000988854 hasConceptScore W2000988854C2781052626 @default.
- W2000988854 hasConceptScore W2000988854C54355233 @default.
- W2000988854 hasConceptScore W2000988854C65290608 @default.
- W2000988854 hasConceptScore W2000988854C71924100 @default.
- W2000988854 hasConceptScore W2000988854C86803240 @default.
- W2000988854 hasConceptScore W2000988854C95444343 @default.
- W2000988854 hasConceptScore W2000988854C98274493 @default.
- W2000988854 hasIssue "4" @default.
- W2000988854 hasLocation W20009888541 @default.
- W2000988854 hasLocation W20009888542 @default.
- W2000988854 hasOpenAccess W2000988854 @default.
- W2000988854 hasPrimaryLocation W20009888541 @default.
- W2000988854 hasRelatedWork W1977361523 @default.
- W2000988854 hasRelatedWork W1984144555 @default.
- W2000988854 hasRelatedWork W1990642671 @default.
- W2000988854 hasRelatedWork W2000988854 @default.
- W2000988854 hasRelatedWork W2029678404 @default.
- W2000988854 hasRelatedWork W2043533487 @default.
- W2000988854 hasRelatedWork W2055942057 @default.
- W2000988854 hasRelatedWork W2132119775 @default.
- W2000988854 hasRelatedWork W2146923313 @default.
- W2000988854 hasRelatedWork W3188395750 @default.
- W2000988854 hasVolume "6" @default.
- W2000988854 isParatext "false" @default.
- W2000988854 isRetracted "false" @default.
- W2000988854 magId "2000988854" @default.
- W2000988854 workType "article" @default.