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- W2000990440 abstract "Compartmentalization of signalling molecules through association with anchoring proteins ensures specificity in signal transduction by placing enzymes close to their appropriate effectors and substrates. For example, 'A-kinase anchoring proteins' (AKAPs) bind to the regulatory subunit of cAMP-dependent protein kinase (PKA) to direct the kinase to discrete intracellular locations. Recently, functional studies aimed at disrupting AKAP-PKA complexes have demonstrated a role for anchored PKA in various cellular processes, including gene transcription, hormone-mediated insulin secretion and ion-channel modulation. By binding to additional signalling molecules, AKAPs might function to coordinate multiple components of signal-transduction pathways." @default.
- W2000990440 created "2016-06-24" @default.
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- W2000990440 date "1999-06-01" @default.
- W2000990440 modified "2023-10-15" @default.
- W2000990440 title "AKAPs: from structure to function" @default.
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- W2000990440 doi "https://doi.org/10.1016/s0962-8924(99)01558-5" @default.
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