Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000990460> ?p ?o ?g. }
- W2000990460 endingPage "5344" @default.
- W2000990460 startingPage "5337" @default.
- W2000990460 abstract "We speculated that peroxisome proliferator-activated receptor (PPAR)-γ agonists may modulate the oxidative stress pathway to ameliorate the development of airway inflammation. The effect of Monascus-fermented metabolite monascin (MS) and rosiglitazone (Rosi) on oxidative stress-induced lung inflammation was evaluated. Luciferase assay and DNA binding activity assay were used to point out that MS may be a novel PPAR-γ agonist and nuclear factor-erythroid 2 related factor 2 (Nrf-2) activator. We used hydrogen peroxide (H2O2) to induce inflammation in lung epithelial cells. MS and Rosi prevented H2O2-induced ROS generation in A549 epithelial cells through PPAR-γ translocation, avoiding inflammatory mediator expression via inhibiting nuclear factor (NF)-κB translocation. The regulatory ability of MS was abolished by siRNA against PPAR-γ. MS also elevated antioxidant enzyme expression via Nrf-2 activation. Both PPAR-γ and Nrf-2 might have benefits against lung inflammation. MS regulated PPAR-γ and Nrf-2 to improve lung oxidative inflammation." @default.
- W2000990460 created "2016-06-24" @default.
- W2000990460 creator A5025628943 @default.
- W2000990460 creator A5063899896 @default.
- W2000990460 creator A5066953235 @default.
- W2000990460 date "2014-06-03" @default.
- W2000990460 modified "2023-09-23" @default.
- W2000990460 title "Monascin Attenuates Oxidative Stress-Mediated Lung Inflammation via Peroxisome Proliferator-Activated Receptor-Gamma (PPAR-γ) and Nuclear Factor-Erythroid 2 Related Factor 2 (Nrf-2) Modulation" @default.
- W2000990460 cites W1546399661 @default.
- W2000990460 cites W1824737122 @default.
- W2000990460 cites W1985361042 @default.
- W2000990460 cites W1989309894 @default.
- W2000990460 cites W1990413035 @default.
- W2000990460 cites W1994994450 @default.
- W2000990460 cites W1999051300 @default.
- W2000990460 cites W1999113566 @default.
- W2000990460 cites W2003115027 @default.
- W2000990460 cites W2006228166 @default.
- W2000990460 cites W2006598330 @default.
- W2000990460 cites W2008201503 @default.
- W2000990460 cites W2021766187 @default.
- W2000990460 cites W2024476729 @default.
- W2000990460 cites W2029759541 @default.
- W2000990460 cites W2030386807 @default.
- W2000990460 cites W2031679199 @default.
- W2000990460 cites W2039193485 @default.
- W2000990460 cites W2041894177 @default.
- W2000990460 cites W2044521211 @default.
- W2000990460 cites W2044895791 @default.
- W2000990460 cites W2049247238 @default.
- W2000990460 cites W2051309543 @default.
- W2000990460 cites W2052818964 @default.
- W2000990460 cites W2064452102 @default.
- W2000990460 cites W2068135486 @default.
- W2000990460 cites W2076485183 @default.
- W2000990460 cites W2090485914 @default.
- W2000990460 cites W2092067512 @default.
- W2000990460 cites W2098114974 @default.
- W2000990460 cites W2099466528 @default.
- W2000990460 cites W2111251212 @default.
- W2000990460 cites W2124569198 @default.
- W2000990460 cites W2138500715 @default.
- W2000990460 cites W2146558971 @default.
- W2000990460 cites W2147243248 @default.
- W2000990460 cites W2158843488 @default.
- W2000990460 cites W2313252270 @default.
- W2000990460 cites W2315481467 @default.
- W2000990460 cites W2318301929 @default.
- W2000990460 cites W2333157744 @default.
- W2000990460 cites W2344493390 @default.
- W2000990460 doi "https://doi.org/10.1021/jf501373a" @default.
- W2000990460 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24865672" @default.
- W2000990460 hasPublicationYear "2014" @default.
- W2000990460 type Work @default.
- W2000990460 sameAs 2000990460 @default.
- W2000990460 citedByCount "29" @default.
- W2000990460 countsByYear W20009904602015 @default.
- W2000990460 countsByYear W20009904602016 @default.
- W2000990460 countsByYear W20009904602017 @default.
- W2000990460 countsByYear W20009904602018 @default.
- W2000990460 countsByYear W20009904602019 @default.
- W2000990460 countsByYear W20009904602020 @default.
- W2000990460 countsByYear W20009904602021 @default.
- W2000990460 countsByYear W20009904602022 @default.
- W2000990460 countsByYear W20009904602023 @default.
- W2000990460 crossrefType "journal-article" @default.
- W2000990460 hasAuthorship W2000990460A5025628943 @default.
- W2000990460 hasAuthorship W2000990460A5063899896 @default.
- W2000990460 hasAuthorship W2000990460A5066953235 @default.
- W2000990460 hasConcept C104317684 @default.
- W2000990460 hasConcept C126322002 @default.
- W2000990460 hasConcept C130241916 @default.
- W2000990460 hasConcept C134018914 @default.
- W2000990460 hasConcept C170493617 @default.
- W2000990460 hasConcept C185592680 @default.
- W2000990460 hasConcept C187345961 @default.
- W2000990460 hasConcept C2776151105 @default.
- W2000990460 hasConcept C2776914184 @default.
- W2000990460 hasConcept C2780152017 @default.
- W2000990460 hasConcept C502942594 @default.
- W2000990460 hasConcept C55493867 @default.
- W2000990460 hasConcept C63932345 @default.
- W2000990460 hasConcept C71924100 @default.
- W2000990460 hasConcept C86339819 @default.
- W2000990460 hasConcept C86803240 @default.
- W2000990460 hasConcept C98274493 @default.
- W2000990460 hasConceptScore W2000990460C104317684 @default.
- W2000990460 hasConceptScore W2000990460C126322002 @default.
- W2000990460 hasConceptScore W2000990460C130241916 @default.
- W2000990460 hasConceptScore W2000990460C134018914 @default.
- W2000990460 hasConceptScore W2000990460C170493617 @default.
- W2000990460 hasConceptScore W2000990460C185592680 @default.
- W2000990460 hasConceptScore W2000990460C187345961 @default.
- W2000990460 hasConceptScore W2000990460C2776151105 @default.
- W2000990460 hasConceptScore W2000990460C2776914184 @default.
- W2000990460 hasConceptScore W2000990460C2780152017 @default.
- W2000990460 hasConceptScore W2000990460C502942594 @default.
- W2000990460 hasConceptScore W2000990460C55493867 @default.