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• W2000991186 abstract "The transcription factor Signal Transducer and Activator of Transcription 3 (Stat3) functions in various cellular processes including neuronal differentiation. We show that the SRY-box containing gene 6 (Sox6) gene, important for neuronal differentiation, is a direct target gene of Stat3. We demonstrate that in response to ligand stimulation, Stat3 binds to the Sox6 promoter and induces its expression. Furthermore, Stat3 is activated and Sox6 is induced during neuronal differentiation of P19 cells in the absence of exogenous ligand treatment. Moreover, using an RNA interference approach, we show that Stat3 is required for Sox6 expression during neuronal differentiation." @default.
• W2000991186 created "2016-06-24" @default.
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• W2000991186 date "2010-11-19" @default.
• W2000991186 modified "2023-09-25" @default.
• W2000991186 title "Stat3 is essential for neuronal differentiation through direct transcriptional regulation of the Sox6 gene" @default.
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• W2000991186 doi "https://doi.org/10.1016/j.febslet.2010.11.030" @default.
• W2000991186 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3022371" @default.
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