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• W2000991731 abstract "본 연구를 통하여 청시닥나무의 에탄올 추출물은 쥐 대식 세포인 Raw264.7 세포에 LPS로 유도된 염증반응에 미치는 효과가 있음을 확인하였다. 청시닥나무 목질부와 수피부에 에탄올을 가하여 추출한 뒤 그 추출물과 분획물의 NO 생성능 및 세포증식능을 실험한 결과 수피부의 EtOAc 분획이 세포증식능에 영향을 주지 않으면서 NO의 생성을 억제함을 확인하였다. 청시닥나무 수피부 에탄올 추출물 EtOAc 분획(EFEBA)은 Raw264.7 세포에서 LPS에 의해 생성된 NO의 분비와 iNOS의 단백질 및 mRNA의 발현을 농도 의존적으로 감소시켰고, 염증 반응 시 생성되는 IL-6, IL-1β 그리고 TNF-α의 mRNA의 발현도 현저히 감소시켰다. 또한 IκBα의 degradation을 감소시키고 p65의 인산화를 감소시켜 NF-κB signaling을 통해 염증작용을 조절함을 확인하였다." @default.
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• W2000991731 date "2012-09-30" @default.
• W2000991731 modified "2023-09-27" @default.
• W2000991731 title "Anti-inflammatory Effects of Ethanol Extract from Bark of Acer barbinerve Maxim" @default.
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• W2000991731 doi "https://doi.org/10.3746/jkfn.2012.41.9.1242" @default.
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