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- W2000992710 abstract "Genomes are composed of nucleic acids bearing 3‘,5‘-phosphodiester-linked sugars. The 2‘,5‘-phosphodiester linkage is a fundamental alternative to the natural linkage and is the predominant product of most nontemplate, nonenzymatic oligomerizations of nucleotide monomers. This fact suggests a chemical bias for the formation of 2‘,5‘-phosphodiester bonds, an important consideration in the context of molecular evolution on Earth or elsewhere. Although 2‘,5‘-linked RNA occurs naturally, it is evidently not used to encode genetic information. Nevertheless, the capacity of the 2‘,5‘-phosphodiester linkage to serve as a genetic material has been probed in laboratory experiments. Initial studies examined both self-pairing and pairing with natural nucleic acids. These studies showed that, while 2‘,5‘-linked DNA and RNA form double and triple helices with themselves, their interactions with natural nucleic acids are asymmetricpairing is seen with 3‘,5‘-linked RNA but not DNA. Although the ability to form a stable structure (such as a helix) is likely a necessary condition for nonenzymatic information transfer, in the case of enzymatic reactions this precondition may be expected to be lifted in cases where the enzyme can serve as a “template for the template” and make up for structural deficiencies that would be fatal to its abiotic counterpart. In support of this suggestion, we demonstrate that 2‘,5‘-linked DNA is a template for enzymatic synthesis of natural DNA with a variety of DNA polymerases and reverse transcriptases directing the incorporation of all four natural nucleotides with fidelity." @default.
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- W2000992710 date "2003-12-12" @default.
- W2000992710 modified "2023-10-03" @default.
- W2000992710 title "2‘,5‘-Linked DNA Is a Template for Polymerase-Directed DNA Synthesis" @default.
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- W2000992710 doi "https://doi.org/10.1021/ja034986z" @default.
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