FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000993895> ?p ?o ?g. }

• W2000993895 endingPage "339" @default.
• W2000993895 startingPage "327" @default.
• W2000993895 abstract "Transcription factors of the SoxE family are critical players that underlie various embryological processes. However, little is known about their function during inner ear development. Here, we show that Sox10 is initially expressed throughout the otic vesicle epithelium and becomes later restricted to supporting cells as cell differentiation proceeds in the organ of Corti. Morphological analyses of Sox10 mutant mice reveal a significant shortening of the cochlear duct likely resulting from the progressive depletion of cochlear progenitors. While Sox10 appears dispensable for the differentiation and patterning of the inner ear prosensory progenitors, our data support a critical role for this transcription factor in the promotion of their survival. We provide genetic evidences that Sox10, in a concentration-dependant manner, could play a role in the regulation of Jagged1, a gene known to be important for inner ear prosensory development. Together, our results demonstrate that Sox10 regulates the biology of early cochlear progenitors during inner ear development, but, in contrast to neural crest-derived cells, this transcription factor is dispensable for their differentiation. Evidence also suggests that this effect occurs via the activation of the Jagged1 gene." @default.
• W2000993895 created "2016-06-24" @default.
• W2000993895 creator A5008132946 @default.
• W2000993895 creator A5022956543 @default.
• W2000993895 creator A5023274254 @default.
• W2000993895 creator A5029427610 @default.
• W2000993895 creator A5046465023 @default.
• W2000993895 creator A5058303994 @default.
• W2000993895 creator A5061600171 @default.
• W2000993895 creator A5073281510 @default.
• W2000993895 date "2009-11-01" @default.
• W2000993895 modified "2023-10-16" @default.
• W2000993895 title "Sox10 promotes the survival of cochlear progenitors during the establishment of the organ of Corti" @default.
• W2000993895 cites W1890207703 @default.
• W2000993895 cites W1902123239 @default.
• W2000993895 cites W1958675029 @default.
• W2000993895 cites W1964009055 @default.
• W2000993895 cites W1976089070 @default.
• W2000993895 cites W1977218716 @default.
• W2000993895 cites W1979495004 @default.
• W2000993895 cites W1980147031 @default.
• W2000993895 cites W1991016615 @default.
• W2000993895 cites W1991750645 @default.
• W2000993895 cites W2004467363 @default.
• W2000993895 cites W2006680452 @default.
• W2000993895 cites W2011864853 @default.
• W2000993895 cites W2013958856 @default.
• W2000993895 cites W2017965913 @default.
• W2000993895 cites W2024299195 @default.
• W2000993895 cites W2025120315 @default.
• W2000993895 cites W2026436551 @default.
• W2000993895 cites W2038510087 @default.
• W2000993895 cites W2043379002 @default.
• W2000993895 cites W2049157134 @default.
• W2000993895 cites W2052902484 @default.
• W2000993895 cites W2059084418 @default.
• W2000993895 cites W2061412347 @default.
• W2000993895 cites W2062418948 @default.
• W2000993895 cites W2083456214 @default.
• W2000993895 cites W2086538740 @default.
• W2000993895 cites W2092027171 @default.
• W2000993895 cites W2092472216 @default.
• W2000993895 cites W2098102650 @default.
• W2000993895 cites W2099181688 @default.
• W2000993895 cites W2099882112 @default.
• W2000993895 cites W2103619902 @default.
• W2000993895 cites W2107277218 @default.
• W2000993895 cites W2109734495 @default.
• W2000993895 cites W2112286579 @default.
• W2000993895 cites W2121833147 @default.
• W2000993895 cites W2123140235 @default.
• W2000993895 cites W2126490946 @default.
• W2000993895 cites W2128080523 @default.
• W2000993895 cites W2128844924 @default.
• W2000993895 cites W2133862424 @default.
• W2000993895 cites W2138192079 @default.
• W2000993895 cites W2138302361 @default.
• W2000993895 cites W2142092370 @default.
• W2000993895 cites W2144773349 @default.
• W2000993895 cites W4246639364 @default.
• W2000993895 doi "https://doi.org/10.1016/j.ydbio.2009.09.007" @default.
• W2000993895 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19748502" @default.
• W2000993895 hasPublicationYear "2009" @default.
• W2000993895 type Work @default.
• W2000993895 sameAs 2000993895 @default.
• W2000993895 citedByCount "43" @default.
• W2000993895 countsByYear W20009938952012 @default.
• W2000993895 countsByYear W20009938952013 @default.
• W2000993895 countsByYear W20009938952014 @default.
• W2000993895 countsByYear W20009938952015 @default.
• W2000993895 countsByYear W20009938952016 @default.
• W2000993895 countsByYear W20009938952017 @default.
• W2000993895 countsByYear W20009938952019 @default.
• W2000993895 countsByYear W20009938952020 @default.
• W2000993895 countsByYear W20009938952021 @default.
• W2000993895 countsByYear W20009938952022 @default.
• W2000993895 countsByYear W20009938952023 @default.
• W2000993895 crossrefType "journal-article" @default.
• W2000993895 hasAuthorship W2000993895A5008132946 @default.
• W2000993895 hasAuthorship W2000993895A5022956543 @default.
• W2000993895 hasAuthorship W2000993895A5023274254 @default.
• W2000993895 hasAuthorship W2000993895A5029427610 @default.
• W2000993895 hasAuthorship W2000993895A5046465023 @default.
• W2000993895 hasAuthorship W2000993895A5058303994 @default.
• W2000993895 hasAuthorship W2000993895A5061600171 @default.
• W2000993895 hasAuthorship W2000993895A5073281510 @default.
• W2000993895 hasBestOaLocation W20009938951 @default.
• W2000993895 hasConcept C104317684 @default.
• W2000993895 hasConcept C105702510 @default.
• W2000993895 hasConcept C126749454 @default.
• W2000993895 hasConcept C150194340 @default.
• W2000993895 hasConcept C15729860 @default.
• W2000993895 hasConcept C196843134 @default.
• W2000993895 hasConcept C201750760 @default.
• W2000993895 hasConcept C2777302934 @default.
• W2000993895 hasConcept C2778500370 @default.
• W2000993895 hasConcept C2778869571 @default.
• W2000993895 hasConcept C2780130748 @default.

• next