Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000994614> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2000994614 endingPage "460" @default.
- W2000994614 startingPage "451" @default.
- W2000994614 abstract "Inotropic versus chronotropic, dromotropic, and vascular effects of DPI 201–106 were assessed in isolated, blood-perfused papillary muscle, sinoatrial (SA) node, and atrioventricular (AV) node preparations of dogs. DPI 201–106 was administered intraarterially. In paced papillary muscles the drug produced an increase in developed tension. In spontaneously beating papillary muscles the drug slightly decreased the beating rate. In SA node preparations the drug decreased sinus rate, and atrial standstill ensued from the highest dose. In AV node preparations the drug affected AV conduction only when administered into the AV node artery, and in high doses second or third--degree AV block occurred. In all preparations the drug increased blood flow. DPI 201–106 at the dose that produced a 50% increase in the force of contraction of ventricular muscle increased coronary blood flow by 8.4%, AV conduction time by 7.6%, and decreased sinus rate by 2.6%, indicating its high selectivity for force. When infused into the AV node artery, the drug in high doses produced dose-dependent prolongations of both the AV nodal conduction time and the functional refractory period of the AV node, which were pronounced with elevation of the pacing rate. These effects of DPI 201–106 are very similar to those of calcium channel blockers." @default.
- W2000994614 created "2016-06-24" @default.
- W2000994614 creator A5021629429 @default.
- W2000994614 creator A5027999029 @default.
- W2000994614 creator A5072393223 @default.
- W2000994614 date "1987-04-01" @default.
- W2000994614 modified "2023-10-14" @default.
- W2000994614 title "Inotropic Versus Chronotropic, Dromotropic, and Coronary Vasodilator Actions of DPI 201–106, a Novel Positive Inotropic Agent, in the Dog Heart" @default.
- W2000994614 doi "https://doi.org/10.1097/00005344-198704000-00010" @default.
- W2000994614 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2438508" @default.
- W2000994614 hasPublicationYear "1987" @default.
- W2000994614 type Work @default.
- W2000994614 sameAs 2000994614 @default.
- W2000994614 citedByCount "8" @default.
- W2000994614 crossrefType "journal-article" @default.
- W2000994614 hasAuthorship W2000994614A5021629429 @default.
- W2000994614 hasAuthorship W2000994614A5027999029 @default.
- W2000994614 hasAuthorship W2000994614A5072393223 @default.
- W2000994614 hasBestOaLocation W20009946141 @default.
- W2000994614 hasConcept C120770815 @default.
- W2000994614 hasConcept C126322002 @default.
- W2000994614 hasConcept C155710745 @default.
- W2000994614 hasConcept C158328960 @default.
- W2000994614 hasConcept C164705383 @default.
- W2000994614 hasConcept C2776024998 @default.
- W2000994614 hasConcept C2776820930 @default.
- W2000994614 hasConcept C2777274916 @default.
- W2000994614 hasConcept C2777953023 @default.
- W2000994614 hasConcept C2778542873 @default.
- W2000994614 hasConcept C2780283014 @default.
- W2000994614 hasConcept C2909076160 @default.
- W2000994614 hasConcept C42219234 @default.
- W2000994614 hasConcept C71924100 @default.
- W2000994614 hasConcept C84393581 @default.
- W2000994614 hasConceptScore W2000994614C120770815 @default.
- W2000994614 hasConceptScore W2000994614C126322002 @default.
- W2000994614 hasConceptScore W2000994614C155710745 @default.
- W2000994614 hasConceptScore W2000994614C158328960 @default.
- W2000994614 hasConceptScore W2000994614C164705383 @default.
- W2000994614 hasConceptScore W2000994614C2776024998 @default.
- W2000994614 hasConceptScore W2000994614C2776820930 @default.
- W2000994614 hasConceptScore W2000994614C2777274916 @default.
- W2000994614 hasConceptScore W2000994614C2777953023 @default.
- W2000994614 hasConceptScore W2000994614C2778542873 @default.
- W2000994614 hasConceptScore W2000994614C2780283014 @default.
- W2000994614 hasConceptScore W2000994614C2909076160 @default.
- W2000994614 hasConceptScore W2000994614C42219234 @default.
- W2000994614 hasConceptScore W2000994614C71924100 @default.
- W2000994614 hasConceptScore W2000994614C84393581 @default.
- W2000994614 hasIssue "4" @default.
- W2000994614 hasLocation W20009946141 @default.
- W2000994614 hasLocation W20009946142 @default.
- W2000994614 hasLocation W20009946143 @default.
- W2000994614 hasOpenAccess W2000994614 @default.
- W2000994614 hasPrimaryLocation W20009946141 @default.
- W2000994614 hasRelatedWork W1997882577 @default.
- W2000994614 hasRelatedWork W2000994614 @default.
- W2000994614 hasRelatedWork W2002457626 @default.
- W2000994614 hasRelatedWork W2014216926 @default.
- W2000994614 hasRelatedWork W2014351854 @default.
- W2000994614 hasRelatedWork W2023308285 @default.
- W2000994614 hasRelatedWork W2031792043 @default.
- W2000994614 hasRelatedWork W2049204330 @default.
- W2000994614 hasRelatedWork W2315955371 @default.
- W2000994614 hasRelatedWork W2326708579 @default.
- W2000994614 hasVolume "9" @default.
- W2000994614 isParatext "false" @default.
- W2000994614 isRetracted "false" @default.
- W2000994614 magId "2000994614" @default.
- W2000994614 workType "article" @default.