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• W2000994765 abstract "Type III secretion for injection of effector proteins into host cells has not been described for Gram-positive bacteria despite their importance in disease. Here, we describe an injection pathway for the Gram-positive pathogen Streptococcus pyogenes that utilizes streptolysin O (SLO), a cholesterol-dependent cytolysin. The data support a model in which an effector is translocated through the SLO pore by a polarized process. The effector, SPN (S. pyogenes NAD-glycohydrolase), is capable of producing the potent second messenger cyclic ADP-ribose, and SLO and SPN act synergistically to trigger cytotoxicity. These data provide a novel paradigm for the function of the cholesterol-dependent cytolysin family and its wide distribution suggests that cytolysin-mediated translocation (CMT) may be the equivalent of type III secretion for Gram-positive pathogens." @default.
• W2000994765 created "2016-06-24" @default.
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• W2000994765 date "2001-01-01" @default.
• W2000994765 modified "2023-10-18" @default.
• W2000994765 title "Cytolysin-Mediated Translocation (CMT)" @default.
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• W2000994765 doi "https://doi.org/10.1016/s0092-8674(01)00198-2" @default.
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