Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000995209> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2000995209 endingPage "218" @default.
- W2000995209 startingPage "211" @default.
- W2000995209 abstract "α-Ketoisocaproic acid has been shown to be apotent insulin secretagogue but the mechanism has not been elucidated. To define the role of β-cell metabolism in the insulinotropic activity of α-ketoisocaproic acid the utilization of glucose and the oxidation of α-ketoisocaproic and isovaleric acid by incubated islets of obese hyperglycemic mice were measured. Glucose metabolism was never enhanced by α-ketoisocaproic acid. The same 14CO2 amounts were released from the non-secretagogue [1-14C]isovaleric acid (10 mM) or from α-keto [2-14C]isocaproic acid (5–20 mM). Pyruvate (20 mM) did not inhibit α-ketoisocaproic acid-induced insulin secretion in spite of reduction of decarboxylation of α-ketoisocaproic acid by more than 40%. The results indicate that stimulated insulin release in response to α-ketoisocaproic acid is not mediated by an indirect increase in glucose metabolism and further suggest that isovaleryl-CoA and following CoA-esters in α-ketoisocaproic acid degradation are not likely recognized as signals. The possibility, however, remains that enhanced intramitochondrial production of reducing equivalents elicits insulin secretion." @default.
- W2000995209 created "2016-06-24" @default.
- W2000995209 creator A5054165332 @default.
- W2000995209 creator A5084450144 @default.
- W2000995209 date "1979-12-01" @default.
- W2000995209 modified "2023-09-26" @default.
- W2000995209 title "Studies on the role of β-cell metabolism in the insulinotropic effect of α-ketoisocaproic acid" @default.
- W2000995209 cites W1595366583 @default.
- W2000995209 cites W1595945663 @default.
- W2000995209 cites W1965649883 @default.
- W2000995209 cites W1992705303 @default.
- W2000995209 cites W2033272273 @default.
- W2000995209 cites W2040761379 @default.
- W2000995209 cites W2043966314 @default.
- W2000995209 cites W2077055589 @default.
- W2000995209 cites W20780901 @default.
- W2000995209 cites W2080449286 @default.
- W2000995209 cites W2150420216 @default.
- W2000995209 cites W2157865424 @default.
- W2000995209 cites W2247538616 @default.
- W2000995209 cites W2396226567 @default.
- W2000995209 doi "https://doi.org/10.1016/0304-4165(79)90204-6" @default.
- W2000995209 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/389294" @default.
- W2000995209 hasPublicationYear "1979" @default.
- W2000995209 type Work @default.
- W2000995209 sameAs 2000995209 @default.
- W2000995209 citedByCount "8" @default.
- W2000995209 countsByYear W20009952092021 @default.
- W2000995209 crossrefType "journal-article" @default.
- W2000995209 hasAuthorship W2000995209A5054165332 @default.
- W2000995209 hasAuthorship W2000995209A5084450144 @default.
- W2000995209 hasConcept C126322002 @default.
- W2000995209 hasConcept C134018914 @default.
- W2000995209 hasConcept C17093226 @default.
- W2000995209 hasConcept C185592680 @default.
- W2000995209 hasConcept C2777179333 @default.
- W2000995209 hasConcept C2779306644 @default.
- W2000995209 hasConcept C2780161494 @default.
- W2000995209 hasConcept C55493867 @default.
- W2000995209 hasConcept C62231903 @default.
- W2000995209 hasConcept C71924100 @default.
- W2000995209 hasConcept C86803240 @default.
- W2000995209 hasConceptScore W2000995209C126322002 @default.
- W2000995209 hasConceptScore W2000995209C134018914 @default.
- W2000995209 hasConceptScore W2000995209C17093226 @default.
- W2000995209 hasConceptScore W2000995209C185592680 @default.
- W2000995209 hasConceptScore W2000995209C2777179333 @default.
- W2000995209 hasConceptScore W2000995209C2779306644 @default.
- W2000995209 hasConceptScore W2000995209C2780161494 @default.
- W2000995209 hasConceptScore W2000995209C55493867 @default.
- W2000995209 hasConceptScore W2000995209C62231903 @default.
- W2000995209 hasConceptScore W2000995209C71924100 @default.
- W2000995209 hasConceptScore W2000995209C86803240 @default.
- W2000995209 hasIssue "2" @default.
- W2000995209 hasLocation W20009952091 @default.
- W2000995209 hasLocation W20009952092 @default.
- W2000995209 hasOpenAccess W2000995209 @default.
- W2000995209 hasPrimaryLocation W20009952091 @default.
- W2000995209 hasRelatedWork W1986933516 @default.
- W2000995209 hasRelatedWork W2023313620 @default.
- W2000995209 hasRelatedWork W2023960546 @default.
- W2000995209 hasRelatedWork W2042617115 @default.
- W2000995209 hasRelatedWork W2054690921 @default.
- W2000995209 hasRelatedWork W2087100186 @default.
- W2000995209 hasRelatedWork W2150247094 @default.
- W2000995209 hasRelatedWork W2150355182 @default.
- W2000995209 hasRelatedWork W2187001057 @default.
- W2000995209 hasRelatedWork W2400635381 @default.
- W2000995209 hasVolume "588" @default.
- W2000995209 isParatext "false" @default.
- W2000995209 isRetracted "false" @default.
- W2000995209 magId "2000995209" @default.
- W2000995209 workType "article" @default.