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- W2000995392 abstract "When soybean oil containing tocopherol acetate was given to rats once a week subcutaneously for 10–12 months, it caused the development of fibrosarcomas at the injection site in 11 of 15 rats. A tumor produced in this manner proved eminently transplantable into other rats. The molecular species of phospholipid subclasses were determined in primary and transplanted tumors. The molecular species composition of the phospholipid subclasses in both types of tumors were similar. The percentages of diacyl and alkylacyl glycerophosphocholine (GPC) were 90–93 and 6–8% of total phosphatidylcholine, respectively. The percentages of diacyl and alkenylacyl glycerophosphoethanolamine (GPE) were 51 and 45%, respectively, of total phosphatidylethanolamine (PE). Diacyl and alkylacyl GPC species containing arachidonic acid (20:4) composed about 15–16 and 37–40% of each subclass, respectively. Diacyl and alkenylacyl GPE species containing 20:4 composed about 38–40 and 56–60% of each subclass, respectively. Disaturated species of diacyl and alkylacyl GPC composed about 22–24 and 13% of each subclass, respectively, whereas these species of PE composed less than 2%. The fatty acid composition of the other tumor phospholipids was analyzed.Key words: phospholipids, molecular species, fibrosarcomas, tocopherol, soybean oil." @default.
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- W2000995392 date "1991-09-01" @default.
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- W2000995392 title "Molecular species of phospholipid in rats in primary and transplanted fibrosarcomas induced by soybean oil containing tocopherol acetate" @default.
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- W2000995392 doi "https://doi.org/10.1139/o91-097" @default.
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