FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000995800> ?p ?o ?g. }

• W2000995800 endingPage "36" @default.
• W2000995800 startingPage "29" @default.
• W2000995800 abstract "The regulators of G-protein signaling (RGS) proteins have been shown to modulate the function of some heterotrimeric G-proteins by stimulating the GTPase activity of G-protein alpha subunits. In this study, by northern blotting analysis, we investigated the regulation of RGS4 mRNA by opioid receptor agonists in PC12 cells stably expressing either cloned mu- or kappa-opioid receptors. Treatment with respective opioid receptor agonists (mu: morphine) and [D-Ala(2), MePhe(4), Gly(ol)(5)] enkephalin (DAMGO), kappa: (+)-(5 alpha,7 alpha,8 beta)-N-methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro-(4,5)dec-8-y1]benzeneacetamide (U69,593)) for 0.5-24 h significantly and transiently increased the expression of RGS4 mRNA by 140-170% of the control level in a concentration-dependent manner which peaked when treated for 2 h, while treatment of non-transfected PC12 cells with opioid receptor agonists did not. The up-regulation of RGS4 mRNA was significantly blocked by co-treatment with respective opioid antagonists (mu: naloxone, kappa: norbinaltorphimine) or pretreatment with pertussis toxin. These results suggest that the activation of mu- or kappa-opioid receptors increases RGS4 mRNA level, which might contribute to opioid desentilization." @default.
• W2000995800 created "2016-06-24" @default.
• W2000995800 creator A5034199613 @default.
• W2000995800 creator A5041951543 @default.
• W2000995800 creator A5070407720 @default.
• W2000995800 date "2001-12-01" @default.
• W2000995800 modified "2023-09-23" @default.
• W2000995800 title "Up-regulation of RGS4 mRNA by opioid receptor agonists in PC12 cells expressing cloned μ- or κ-opioid receptors" @default.
• W2000995800 cites W1517670533 @default.
• W2000995800 cites W1614895539 @default.
• W2000995800 cites W1945832201 @default.
• W2000995800 cites W1970361438 @default.
• W2000995800 cites W1970820951 @default.
• W2000995800 cites W1974674594 @default.
• W2000995800 cites W1981891173 @default.
• W2000995800 cites W1989817592 @default.
• W2000995800 cites W1990746404 @default.
• W2000995800 cites W1993485378 @default.
• W2000995800 cites W1996293071 @default.
• W2000995800 cites W2013245863 @default.
• W2000995800 cites W2021832717 @default.
• W2000995800 cites W2029445497 @default.
• W2000995800 cites W2034762105 @default.
• W2000995800 cites W2042030773 @default.
• W2000995800 cites W2042221669 @default.
• W2000995800 cites W2045960840 @default.
• W2000995800 cites W2054004023 @default.
• W2000995800 cites W2062897867 @default.
• W2000995800 cites W2064734596 @default.
• W2000995800 cites W2067477282 @default.
• W2000995800 cites W2071242185 @default.
• W2000995800 cites W2071998745 @default.
• W2000995800 cites W2073223681 @default.
• W2000995800 cites W2073503969 @default.
• W2000995800 cites W2081426683 @default.
• W2000995800 cites W2089291669 @default.
• W2000995800 cites W2092975281 @default.
• W2000995800 cites W2095013577 @default.
• W2000995800 cites W2108802560 @default.
• W2000995800 cites W2110458673 @default.
• W2000995800 cites W2125468282 @default.
• W2000995800 cites W2133321625 @default.
• W2000995800 cites W2136972830 @default.
• W2000995800 cites W2140257707 @default.
• W2000995800 cites W2140909611 @default.
• W2000995800 cites W2148882351 @default.
• W2000995800 cites W2163364932 @default.
• W2000995800 cites W2168445861 @default.
• W2000995800 cites W2409332624 @default.
• W2000995800 cites W4238609720 @default.
• W2000995800 cites W4319688303 @default.
• W2000995800 doi "https://doi.org/10.1016/s0014-2999(01)01485-6" @default.
• W2000995800 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11755131" @default.
• W2000995800 hasPublicationYear "2001" @default.
• W2000995800 type Work @default.
• W2000995800 sameAs 2000995800 @default.
• W2000995800 citedByCount "33" @default.
• W2000995800 countsByYear W20009958002012 @default.
• W2000995800 countsByYear W20009958002014 @default.
• W2000995800 countsByYear W20009958002016 @default.
• W2000995800 countsByYear W20009958002020 @default.
• W2000995800 crossrefType "journal-article" @default.
• W2000995800 hasAuthorship W2000995800A5034199613 @default.
• W2000995800 hasAuthorship W2000995800A5041951543 @default.
• W2000995800 hasAuthorship W2000995800A5070407720 @default.
• W2000995800 hasConcept C126322002 @default.
• W2000995800 hasConcept C134018914 @default.
• W2000995800 hasConcept C139407321 @default.
• W2000995800 hasConcept C14397066 @default.
• W2000995800 hasConcept C170493617 @default.
• W2000995800 hasConcept C184389661 @default.
• W2000995800 hasConcept C185592680 @default.
• W2000995800 hasConcept C2776401185 @default.
• W2000995800 hasConcept C2778750930 @default.
• W2000995800 hasConcept C2779886867 @default.
• W2000995800 hasConcept C2781063702 @default.
• W2000995800 hasConcept C49773422 @default.
• W2000995800 hasConcept C55493867 @default.
• W2000995800 hasConcept C71924100 @default.
• W2000995800 hasConcept C80631254 @default.
• W2000995800 hasConcept C86803240 @default.
• W2000995800 hasConcept C98274493 @default.
• W2000995800 hasConceptScore W2000995800C126322002 @default.
• W2000995800 hasConceptScore W2000995800C134018914 @default.
• W2000995800 hasConceptScore W2000995800C139407321 @default.
• W2000995800 hasConceptScore W2000995800C14397066 @default.
• W2000995800 hasConceptScore W2000995800C170493617 @default.
• W2000995800 hasConceptScore W2000995800C184389661 @default.
• W2000995800 hasConceptScore W2000995800C185592680 @default.
• W2000995800 hasConceptScore W2000995800C2776401185 @default.
• W2000995800 hasConceptScore W2000995800C2778750930 @default.
• W2000995800 hasConceptScore W2000995800C2779886867 @default.
• W2000995800 hasConceptScore W2000995800C2781063702 @default.
• W2000995800 hasConceptScore W2000995800C49773422 @default.
• W2000995800 hasConceptScore W2000995800C55493867 @default.
• W2000995800 hasConceptScore W2000995800C71924100 @default.
• W2000995800 hasConceptScore W2000995800C80631254 @default.
• W2000995800 hasConceptScore W2000995800C86803240 @default.

• next