FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000996330> ?p ?o ?g. }

• W2000996330 endingPage "544" @default.
• W2000996330 startingPage "537" @default.
• W2000996330 abstract "Introduction Chemical stimulation with capsaicin in the intestinal lumen induces abdominal pain, presumably through a mechanism involving the polymodal vanilloid receptor TRPV1 (transient receptor potential vanilloid receptor subtype 1). Other stimulators of TRPV1 include heat, acid or ethanol. We evaluated the effects of duodenal acid and ethanol exposure on chemosensitivity and mechanosensitivity in healthy volunteers. Methods In two placebo-controlled arms of the study, healthy volunteers received duodenal infusions of either hydrochloric acid (0.1 mol/l) (n=8) or ethanol (5% vol/vol) through an oroduodenal tube. Mechanosensitivity was tested applying pressure-controlled duodenal distensions and chemosensitivity was tested by duodenal perfusion with capsaicin (40 μg/ml; 2.5 ml/min). Quality and intensity of upper abdominal symptoms were evaluated with a graded questionnaire during mechanical and chemical stimulation of the duodenum. Results During hydrochloric acid infusion, capsaicin-induced perception was reduced (P<0.01) and latency to discomfort was increased from 24.5 min (25th/75th%:16.5/36 min) during placebo to 50 min (25.5/60 min) (P<0.01). Ethanol had no significant effect on chemosensitivity [latency to discomfort for placebo vs. ethanol: 26 min (18/40 min) vs. 20 min (9/60 min)] (P>0.05). Neither duodenal acidification nor ethanol altered mechanosensitivity significantly (P>0.05). Conclusion Duodenal acid activated mechanisms that lead to a decreased sensitivity for intraluminal capsaicin; these mechanisms might protect duodenal chemonociceptors from being sensitized by acid. Whether this mechanism is impaired in patients with upper gastrointestinal functional disease remains to be determined." @default.
• W2000996330 created "2016-06-24" @default.
• W2000996330 creator A5001991428 @default.
• W2000996330 creator A5030256084 @default.
• W2000996330 date "2008-06-01" @default.
• W2000996330 modified "2023-10-12" @default.
• W2000996330 title "Duodenal chemosensitivity and mechanosensitivity in humans during acid and ethanol perfusion" @default.
• W2000996330 cites W1488329806 @default.
• W2000996330 cites W1511198581 @default.
• W2000996330 cites W1549665175 @default.
• W2000996330 cites W1964014908 @default.
• W2000996330 cites W1972197574 @default.
• W2000996330 cites W1979536638 @default.
• W2000996330 cites W1988091706 @default.
• W2000996330 cites W2015553609 @default.
• W2000996330 cites W2018016487 @default.
• W2000996330 cites W2022135315 @default.
• W2000996330 cites W2023736621 @default.
• W2000996330 cites W2044974031 @default.
• W2000996330 cites W2049528386 @default.
• W2000996330 cites W2051960633 @default.
• W2000996330 cites W2078980646 @default.
• W2000996330 cites W2083909172 @default.
• W2000996330 cites W2095020998 @default.
• W2000996330 cites W2097701391 @default.
• W2000996330 cites W2107705149 @default.
• W2000996330 cites W21108368 @default.
• W2000996330 cites W2118842320 @default.
• W2000996330 cites W2124141753 @default.
• W2000996330 cites W2126361487 @default.
• W2000996330 cites W2141539606 @default.
• W2000996330 cites W2141830817 @default.
• W2000996330 cites W2142704202 @default.
• W2000996330 cites W2156521489 @default.
• W2000996330 cites W2171717653 @default.
• W2000996330 cites W242125427 @default.
• W2000996330 cites W4234810391 @default.
• W2000996330 doi "https://doi.org/10.1097/meg.0b013e3282f4e895" @default.
• W2000996330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18467913" @default.
• W2000996330 hasPublicationYear "2008" @default.
• W2000996330 type Work @default.
• W2000996330 sameAs 2000996330 @default.
• W2000996330 citedByCount "11" @default.
• W2000996330 countsByYear W20009963302012 @default.
• W2000996330 countsByYear W20009963302017 @default.
• W2000996330 countsByYear W20009963302018 @default.
• W2000996330 crossrefType "journal-article" @default.
• W2000996330 hasAuthorship W2000996330A5001991428 @default.
• W2000996330 hasAuthorship W2000996330A5030256084 @default.
• W2000996330 hasConcept C126322002 @default.
• W2000996330 hasConcept C134018914 @default.
• W2000996330 hasConcept C142724271 @default.
• W2000996330 hasConcept C146957229 @default.
• W2000996330 hasConcept C155164980 @default.
• W2000996330 hasConcept C160145004 @default.
• W2000996330 hasConcept C170493617 @default.
• W2000996330 hasConcept C204787440 @default.
• W2000996330 hasConcept C24998067 @default.
• W2000996330 hasConcept C27081682 @default.
• W2000996330 hasConcept C2776809568 @default.
• W2000996330 hasConcept C2777504413 @default.
• W2000996330 hasConcept C2779422922 @default.
• W2000996330 hasConcept C2780051329 @default.
• W2000996330 hasConcept C42219234 @default.
• W2000996330 hasConcept C71924100 @default.
• W2000996330 hasConcept C90924648 @default.
• W2000996330 hasConcept C98274493 @default.
• W2000996330 hasConceptScore W2000996330C126322002 @default.
• W2000996330 hasConceptScore W2000996330C134018914 @default.
• W2000996330 hasConceptScore W2000996330C142724271 @default.
• W2000996330 hasConceptScore W2000996330C146957229 @default.
• W2000996330 hasConceptScore W2000996330C155164980 @default.
• W2000996330 hasConceptScore W2000996330C160145004 @default.
• W2000996330 hasConceptScore W2000996330C170493617 @default.
• W2000996330 hasConceptScore W2000996330C204787440 @default.
• W2000996330 hasConceptScore W2000996330C24998067 @default.
• W2000996330 hasConceptScore W2000996330C27081682 @default.
• W2000996330 hasConceptScore W2000996330C2776809568 @default.
• W2000996330 hasConceptScore W2000996330C2777504413 @default.
• W2000996330 hasConceptScore W2000996330C2779422922 @default.
• W2000996330 hasConceptScore W2000996330C2780051329 @default.
• W2000996330 hasConceptScore W2000996330C42219234 @default.
• W2000996330 hasConceptScore W2000996330C71924100 @default.
• W2000996330 hasConceptScore W2000996330C90924648 @default.
• W2000996330 hasConceptScore W2000996330C98274493 @default.
• W2000996330 hasIssue "6" @default.
• W2000996330 hasLocation W20009963301 @default.
• W2000996330 hasLocation W20009963302 @default.
• W2000996330 hasOpenAccess W2000996330 @default.
• W2000996330 hasPrimaryLocation W20009963301 @default.
• W2000996330 hasRelatedWork W1986072332 @default.
• W2000996330 hasRelatedWork W2013659300 @default.
• W2000996330 hasRelatedWork W2048812251 @default.
• W2000996330 hasRelatedWork W2139389244 @default.
• W2000996330 hasRelatedWork W2281887241 @default.
• W2000996330 hasRelatedWork W2334470388 @default.
• W2000996330 hasRelatedWork W2441719627 @default.
• W2000996330 hasRelatedWork W3047177116 @default.

• next