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• W2000996770 abstract "<b><i>Background:</i></b> Vitamin D seems to influence the evolution of atopic dermatitis (AD) in children. <b><i>Methods:</i></b> We tested the vitamin D serum levels of 39 children with AD (AD group t&#8320;) and of 20 nonallergic healthy controls (C group). AD severity was evaluated using the AD scoring system (SCORAD index). Cytokine serum levels (IL-2, IL-4, IL-6, IFN-&#947;, TNF-α) and atopy biomarkers were also measured. The patients were then treated with vitamin D oral supplementation of 1,000 IU/day (25 mg/day) for 3 months. We then reevaluated the vitamin D serum levels, AD severity and cytokine serum levels in all of the treated children (AD group t₁). <b><i>Results:</i></b> The cross-sectional analysis on patients affected by AD (AD group t&#8320;) showed that the initial levels of all the tested cytokines except for TNF-α were higher than those of the healthy control group (C group), falling outside the normal range. After 3 months of supplementation the patients had significantly increased vitamin D levels (from 22.97 ± 8.03 to 29.41 ± 10.73 ng/ml; p = 0.01). A concomitant significant reduction of both the SCORAD index (46.13 ± 15.68 at the first visit vs. 22.57 ± 15.28 at the second visit; p < 0.001) and of all the altered cytokines (IL-2, IL-4, IL-6, IFN-&#947;) was also found. <b><i>Conclusions:</i></b> This study showed vitamin D supplementation to be an effective treatment in reducing AD severity in children through normalization of the Th1 and Th2 interleukin serum pattern." @default.
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• W2000996770 date "2015-01-01" @default.
• W2000996770 modified "2023-10-05" @default.
• W2000996770 title "Vitamin D Supplementation Modulates the Immune System and Improves Atopic Dermatitis in Children" @default.
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• W2000996770 doi "https://doi.org/10.1159/000371350" @default.
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