FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000997307> ?p ?o ?g. }

• W2000997307 endingPage "25" @default.
• W2000997307 startingPage "20" @default.
• W2000997307 abstract "To objective of this work was to study the feasibility of iontophoretic delivery of SLV 318 (7-(4-benzyl-1-piperazinyl)-2(3H)-benzoxazolone methanesulfonate) across hairless rat skin in vitro and in vivo. The effect of counter-ions and temperature were investigated for optimizing SLV 318 solubility. The effect of electrode efficiency and total current applied on the delivery of SLV 318 were studied using Franz diffusion cells and samples were analyzed using HPLC. Delivery increased with increasing concentration. For current–time combinations, electrode had to be replaced every 9 h. Passive, iontophoretic (0.1 mA/cm2 for 1 h) and intravenous studies were performed in vivo. Blood samples collected were analyzed using LC–MS/MS. SLV 318 had higher solubility with NaCl (75 mM) as a counter-ion at 25 °C than with other counter-ions tested. In vivo iontophoresis significantly enhanced the permeation and also reduced its lag time (P < 0.05). The Cmax of SLV 318 during 1 h iontophoresis was 6.56 ± 0.68 ng/mL at 1.31 ± 0.29 h (Tmax) as compared to 2.96 ± 0.29 ng/mL at 25.32 ± 0.67 h (Tmax) by 24 h passive permeation. The in vitro and in vivo data has shown the feasibility to enhance delivery of SLV 318 by iontophoresis." @default.
• W2000997307 created "2016-06-24" @default.
• W2000997307 creator A5009734711 @default.
• W2000997307 creator A5044992258 @default.
• W2000997307 creator A5066619581 @default.
• W2000997307 creator A5073743407 @default.
• W2000997307 creator A5074315776 @default.
• W2000997307 creator A5083897672 @default.
• W2000997307 creator A5087277745 @default.
• W2000997307 date "2011-11-01" @default.
• W2000997307 modified "2023-09-26" @default.
• W2000997307 title "In vitro and in vivo iontophoretic transdermal delivery of an anti-parkinsonian agent" @default.
• W2000997307 cites W1441581468 @default.
• W2000997307 cites W1506736245 @default.
• W2000997307 cites W1967353782 @default.
• W2000997307 cites W1997488570 @default.
• W2000997307 cites W2011044581 @default.
• W2000997307 cites W2037393974 @default.
• W2000997307 cites W2046748538 @default.
• W2000997307 cites W2047371009 @default.
• W2000997307 cites W2049004022 @default.
• W2000997307 cites W2055904302 @default.
• W2000997307 cites W2067926704 @default.
• W2000997307 cites W2077389407 @default.
• W2000997307 cites W2083572003 @default.
• W2000997307 cites W2115092572 @default.
• W2000997307 cites W2141311399 @default.
• W2000997307 cites W2165307652 @default.
• W2000997307 cites W3102433126 @default.
• W2000997307 cites W69345561 @default.
• W2000997307 cites W1770168638 @default.
• W2000997307 doi "https://doi.org/10.1016/j.ijpharm.2011.08.013" @default.
• W2000997307 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21856395" @default.
• W2000997307 hasPublicationYear "2011" @default.
• W2000997307 type Work @default.
• W2000997307 sameAs 2000997307 @default.
• W2000997307 citedByCount "4" @default.
• W2000997307 countsByYear W20009973072012 @default.
• W2000997307 countsByYear W20009973072013 @default.
• W2000997307 countsByYear W20009973072016 @default.
• W2000997307 countsByYear W20009973072020 @default.
• W2000997307 crossrefType "journal-article" @default.
• W2000997307 hasAuthorship W2000997307A5009734711 @default.
• W2000997307 hasAuthorship W2000997307A5044992258 @default.
• W2000997307 hasAuthorship W2000997307A5066619581 @default.
• W2000997307 hasAuthorship W2000997307A5073743407 @default.
• W2000997307 hasAuthorship W2000997307A5074315776 @default.
• W2000997307 hasAuthorship W2000997307A5083897672 @default.
• W2000997307 hasAuthorship W2000997307A5087277745 @default.
• W2000997307 hasConcept C112705442 @default.
• W2000997307 hasConcept C126838900 @default.
• W2000997307 hasConcept C150903083 @default.
• W2000997307 hasConcept C183529106 @default.
• W2000997307 hasConcept C185592680 @default.
• W2000997307 hasConcept C205679159 @default.
• W2000997307 hasConcept C207001950 @default.
• W2000997307 hasConcept C22979827 @default.
• W2000997307 hasConcept C41625074 @default.
• W2000997307 hasConcept C43617362 @default.
• W2000997307 hasConcept C50670333 @default.
• W2000997307 hasConcept C55493867 @default.
• W2000997307 hasConcept C71924100 @default.
• W2000997307 hasConcept C86803240 @default.
• W2000997307 hasConcept C98274493 @default.
• W2000997307 hasConceptScore W2000997307C112705442 @default.
• W2000997307 hasConceptScore W2000997307C126838900 @default.
• W2000997307 hasConceptScore W2000997307C150903083 @default.
• W2000997307 hasConceptScore W2000997307C183529106 @default.
• W2000997307 hasConceptScore W2000997307C185592680 @default.
• W2000997307 hasConceptScore W2000997307C205679159 @default.
• W2000997307 hasConceptScore W2000997307C207001950 @default.
• W2000997307 hasConceptScore W2000997307C22979827 @default.
• W2000997307 hasConceptScore W2000997307C41625074 @default.
• W2000997307 hasConceptScore W2000997307C43617362 @default.
• W2000997307 hasConceptScore W2000997307C50670333 @default.
• W2000997307 hasConceptScore W2000997307C55493867 @default.
• W2000997307 hasConceptScore W2000997307C71924100 @default.
• W2000997307 hasConceptScore W2000997307C86803240 @default.
• W2000997307 hasConceptScore W2000997307C98274493 @default.
• W2000997307 hasIssue "1" @default.
• W2000997307 hasLocation W20009973071 @default.
• W2000997307 hasLocation W20009973072 @default.
• W2000997307 hasOpenAccess W2000997307 @default.
• W2000997307 hasPrimaryLocation W20009973071 @default.
• W2000997307 hasRelatedWork W1940437771 @default.
• W2000997307 hasRelatedWork W2000997307 @default.
• W2000997307 hasRelatedWork W2057097799 @default.
• W2000997307 hasRelatedWork W2084589676 @default.
• W2000997307 hasRelatedWork W2299345868 @default.
• W2000997307 hasRelatedWork W2479254611 @default.
• W2000997307 hasRelatedWork W3000071749 @default.
• W2000997307 hasRelatedWork W3033362092 @default.
• W2000997307 hasRelatedWork W3160151659 @default.
• W2000997307 hasRelatedWork W4286882036 @default.
• W2000997307 hasVolume "420" @default.
• W2000997307 isParatext "false" @default.
• W2000997307 isRetracted "false" @default.
• W2000997307 magId "2000997307" @default.

• next