FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000997424> ?p ?o ?g. }

• W2000997424 endingPage "S717" @default.
• W2000997424 startingPage "S716" @default.
• W2000997424 abstract "The recent advances in diagnosis and treatment of breast cancer have resulted in an increasing number of long-term survivors. However, this population has suffered the consequences of breast cancer treatment, which usually involves radiotherapy. Moreover, recent studies have shown the value of supraclavicular lymph nodes irradiation, even with only one positive axillar lymph node. Since a portion of the thyroid gland may also be included in the treatment fields, hypothyroidism, which has already been described as a well-known phenomenon following irradiation for Hodgkin's disease and head and neck tumors, should be considered a potential late complication of breast cancer radiotherapy. In one of the few studies found in literature, Reinertsen observed the prevalence of 18% of hypothyroidism in 403 patients submitted to breast radiotherapy, compared to 6% in the general population. The total dose received by the gland may play a major role in the incidence of hypothyroidism. Constin found hypothyroidism in 17% of children who received doses below 26 Gy to the thyroid, compared to 78% who received more than 26 Gy, in a study of children treated for group treated for Hodgkin's disease. Eighteen women eligible for breast and supraclavicular radiation were evaluated in order to quantify the absorbed dose of the thyroid parenchyma. Three lithium fluoride TLD-100 thermoluminescent dosimeters (TLDs) measuring 3 mm x 3 mm x 1 mm were used for dose measurement and positioned on the right and left lobes and the isthmus, and each patient was submitted to three measurements. The treatment planning was based on transverse CT images using a commercial treatment planning system, consisting in a field arrangement of an anterior supraclavicular and two tangential fields. The cranial supraclavicular edge of the target volume was 1 cm below the larynx, whereas the medial edge was defined 1 cm lateral to the trachea down to the sternoclavicular junction. Photons of 6 MV were used for all treatment fields, and 50 Gy in 25 fractions were prescribed at 3cm depth. The mean maximum dose observed in the entire gland was 605cGy, varying between 2.48% and 35% of the prescribed dose. The ipsilateral and the contralateral thyroid lobe, as well as the isthmus received a mean dose of 593cGy, 296cGy and 249cGy respectively, which corresponds to 11.8%, 5.9% and 4.9% of the prescribed dose. Despite the fact that the measured values were below the total dose of 26 Gy, the thyroid gland dose was higher than expected, in some cases reaching almost 35% of the prescribed dose. Hypothyroidism following breast radiotherapy could be an underestimated complication, hence the importance of monitoring the function of the thyroid gland in these patients." @default.
• W2000997424 created "2016-06-24" @default.
• W2000997424 creator A5013389698 @default.
• W2000997424 creator A5019862045 @default.
• W2000997424 creator A5035911782 @default.
• W2000997424 creator A5064007358 @default.
• W2000997424 creator A5081847723 @default.
• W2000997424 date "2010-11-01" @default.
• W2000997424 modified "2023-10-17" @default.
• W2000997424 title "In Vivo Dosimetry Analysis of Thyroid Gland Dose in Breast Cancer Patients with Supraclavicular Lymph Node Irradiation" @default.
• W2000997424 doi "https://doi.org/10.1016/j.ijrobp.2010.07.1660" @default.
• W2000997424 hasPublicationYear "2010" @default.
• W2000997424 type Work @default.
• W2000997424 sameAs 2000997424 @default.
• W2000997424 citedByCount "0" @default.
• W2000997424 crossrefType "journal-article" @default.
• W2000997424 hasAuthorship W2000997424A5013389698 @default.
• W2000997424 hasAuthorship W2000997424A5019862045 @default.
• W2000997424 hasAuthorship W2000997424A5035911782 @default.
• W2000997424 hasAuthorship W2000997424A5064007358 @default.
• W2000997424 hasAuthorship W2000997424A5081847723 @default.
• W2000997424 hasBestOaLocation W20009974241 @default.
• W2000997424 hasConcept C105636585 @default.
• W2000997424 hasConcept C121608353 @default.
• W2000997424 hasConcept C126322002 @default.
• W2000997424 hasConcept C126838900 @default.
• W2000997424 hasConcept C148325268 @default.
• W2000997424 hasConcept C2779223589 @default.
• W2000997424 hasConcept C2779761222 @default.
• W2000997424 hasConcept C2780849966 @default.
• W2000997424 hasConcept C2908647359 @default.
• W2000997424 hasConcept C2989005 @default.
• W2000997424 hasConcept C509974204 @default.
• W2000997424 hasConcept C526584372 @default.
• W2000997424 hasConcept C530470458 @default.
• W2000997424 hasConcept C71924100 @default.
• W2000997424 hasConcept C75088862 @default.
• W2000997424 hasConcept C99454951 @default.
• W2000997424 hasConceptScore W2000997424C105636585 @default.
• W2000997424 hasConceptScore W2000997424C121608353 @default.
• W2000997424 hasConceptScore W2000997424C126322002 @default.
• W2000997424 hasConceptScore W2000997424C126838900 @default.
• W2000997424 hasConceptScore W2000997424C148325268 @default.
• W2000997424 hasConceptScore W2000997424C2779223589 @default.
• W2000997424 hasConceptScore W2000997424C2779761222 @default.
• W2000997424 hasConceptScore W2000997424C2780849966 @default.
• W2000997424 hasConceptScore W2000997424C2908647359 @default.
• W2000997424 hasConceptScore W2000997424C2989005 @default.
• W2000997424 hasConceptScore W2000997424C509974204 @default.
• W2000997424 hasConceptScore W2000997424C526584372 @default.
• W2000997424 hasConceptScore W2000997424C530470458 @default.
• W2000997424 hasConceptScore W2000997424C71924100 @default.
• W2000997424 hasConceptScore W2000997424C75088862 @default.
• W2000997424 hasConceptScore W2000997424C99454951 @default.
• W2000997424 hasIssue "3" @default.
• W2000997424 hasLocation W20009974241 @default.
• W2000997424 hasOpenAccess W2000997424 @default.
• W2000997424 hasPrimaryLocation W20009974241 @default.
• W2000997424 hasRelatedWork W1760548340 @default.
• W2000997424 hasRelatedWork W1979123842 @default.
• W2000997424 hasRelatedWork W1998384890 @default.
• W2000997424 hasRelatedWork W2048200321 @default.
• W2000997424 hasRelatedWork W2050101289 @default.
• W2000997424 hasRelatedWork W2063470859 @default.
• W2000997424 hasRelatedWork W2119362991 @default.
• W2000997424 hasRelatedWork W2363960850 @default.
• W2000997424 hasRelatedWork W2470853883 @default.
• W2000997424 hasRelatedWork W2789136111 @default.
• W2000997424 hasVolume "78" @default.
• W2000997424 isParatext "false" @default.
• W2000997424 isRetracted "false" @default.
• W2000997424 magId "2000997424" @default.
• W2000997424 workType "article" @default.