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- W2000997634 abstract "The aim of this study was to compare the Lp(a) concentration and the frequency distribution of the apo(a) isoforms of a myocardial infarcted male group under 60 years old and a group of healthy subjects (controls).A total of 111 infarcted men and 99 men free from disease were enrolled in this study. Lp(a) concentrations were measured by a commercial available rate nephelometry method, and apolipoprotein(a) isoform analysis was performed by sodium dodecyl sulfate (SDS) polyacrilamide gel electrophoresis (PAGE) and immunoblotting.Infarcted patients had higher Lp(a) concentrations (0.33 +/- 0.36 g/l) than noninfarcted subjects did (0.19 +/- 0.22 g/l), and these differences were significant (P = 0.001). Infarcted patients have also shown a greater proportion of elevated (> or = 0.30 g/l) Lp(a) concentrations 37.8% than controls 20.2% (P < 0.01). The distributions of apo(a) phenotypes for patients with myocardial infarction and controls were remarkably different (P < 0.001), and the proportions of smaller isoforms were significantly different by chi-square analysis (P < 0.01).Infarcted patients under 60 years old display higher Lp(a) concentrations and a significantly higher proportion of low molecular weight apolipoprotein(a) isoforms than controls." @default.
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- W2000997634 date "2004-10-01" @default.
- W2000997634 modified "2023-09-24" @default.
- W2000997634 title "Apolipoprotein(a) isoforms in infarcted men under 60 years old" @default.
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- W2000997634 doi "https://doi.org/10.1016/j.clinbiochem.2003.06.001" @default.
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