FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000998004> ?p ?o ?g. }

• W2000998004 endingPage "111" @default.
• W2000998004 startingPage "97" @default.
• W2000998004 abstract "The sensitivity of alphabetagamma rat epithelial Na+ channel (rENaC) to osmotically or mechanically induced changes of membrane tension was investigated in the Xenopus oocyte expression system, using both dual electrode voltage clamp and cell-attached patch clamp methodologies. ENaC whole-cell currents were insensitive to mechanical cell swelling caused by direct injection of 90 or 180 nl of 100-mM KCl. Similarly, ENaC whole-cell currents were insensitive to osmotic cell swelling caused by a 33% decrease of bathing solution osmolarity. The lack of an effect of cell swelling on ENaC was independent of the status of the actin cytoskeleton, as ENaC remained insensitive to osmotic and mechanical cell swelling in oocytes pretreated with cytochalasin B for 2-5 h. This apparent insensitivity of ENaC to increased cell volume and changes of membrane tension was also observed at the single channel level in membrane patches subjected to negative or positive pressures of 5 or 10 in. of water. However, and contrary to the lack of an effect of cell swelling, ENaC currents were inhibited by cell shrinking. A 45-min incubation in a 260-mosmol solution (a 25% increase of solution osmolarity) caused a decrease of ENaC currents (at -100 mV) from -3.42 +/- 0.34 to -2.02 +/- 0.23 microA (n = 6). This decrease of current with cell shrinking was completely blocked by pretreatment of oocytes with cytochalasin B, indicating that these changes of current are not likely related to a direct effect of cell shrinking. We conclude that alpha beta gamma rENaC is not directly mechanosensitive when expressed in a system that can produce a channel with identical properties to those found in native epithelia." @default.
• W2000998004 created "2016-06-24" @default.
• W2000998004 creator A5060448700 @default.
• W2000998004 creator A5086495272 @default.
• W2000998004 date "1998-08-01" @default.
• W2000998004 modified "2023-10-01" @default.
• W2000998004 title "Regulation of the Epithelial Na+ Channel by Membrane Tension" @default.
• W2000998004 cites W1506512444 @default.
• W2000998004 cites W1850052335 @default.
• W2000998004 cites W1887182106 @default.
• W2000998004 cites W1977987849 @default.
• W2000998004 cites W1997511216 @default.
• W2000998004 cites W2009304256 @default.
• W2000998004 cites W2009667219 @default.
• W2000998004 cites W2010899765 @default.
• W2000998004 cites W2011277110 @default.
• W2000998004 cites W2015426350 @default.
• W2000998004 cites W2025720625 @default.
• W2000998004 cites W2043502742 @default.
• W2000998004 cites W2079573668 @default.
• W2000998004 cites W2087499467 @default.
• W2000998004 cites W2090117730 @default.
• W2000998004 cites W2098159540 @default.
• W2000998004 cites W2120245762 @default.
• W2000998004 cites W2126076477 @default.
• W2000998004 cites W2133136550 @default.
• W2000998004 cites W2158352565 @default.
• W2000998004 cites W2158888624 @default.
• W2000998004 cites W2224842634 @default.
• W2000998004 cites W2514542591 @default.
• W2000998004 doi "https://doi.org/10.1085/jgp.112.2.97" @default.
• W2000998004 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2525750" @default.
• W2000998004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9689021" @default.
• W2000998004 hasPublicationYear "1998" @default.
• W2000998004 type Work @default.
• W2000998004 sameAs 2000998004 @default.
• W2000998004 citedByCount "80" @default.
• W2000998004 countsByYear W20009980042012 @default.
• W2000998004 countsByYear W20009980042013 @default.
• W2000998004 countsByYear W20009980042014 @default.
• W2000998004 countsByYear W20009980042015 @default.
• W2000998004 countsByYear W20009980042016 @default.
• W2000998004 countsByYear W20009980042017 @default.
• W2000998004 countsByYear W20009980042020 @default.
• W2000998004 countsByYear W20009980042021 @default.
• W2000998004 countsByYear W20009980042022 @default.
• W2000998004 countsByYear W20009980042023 @default.
• W2000998004 crossrefType "journal-article" @default.
• W2000998004 hasAuthorship W2000998004A5060448700 @default.
• W2000998004 hasAuthorship W2000998004A5086495272 @default.
• W2000998004 hasBestOaLocation W20009980041 @default.
• W2000998004 hasConcept C12554922 @default.
• W2000998004 hasConcept C129900496 @default.
• W2000998004 hasConcept C142669718 @default.
• W2000998004 hasConcept C147944092 @default.
• W2000998004 hasConcept C1491633281 @default.
• W2000998004 hasConcept C159985019 @default.
• W2000998004 hasConcept C170493617 @default.
• W2000998004 hasConcept C178790620 @default.
• W2000998004 hasConcept C185592680 @default.
• W2000998004 hasConcept C192562407 @default.
• W2000998004 hasConcept C2775995422 @default.
• W2000998004 hasConcept C2776041460 @default.
• W2000998004 hasConcept C2778106830 @default.
• W2000998004 hasConcept C2778540859 @default.
• W2000998004 hasConcept C2779012151 @default.
• W2000998004 hasConcept C537181965 @default.
• W2000998004 hasConcept C55493867 @default.
• W2000998004 hasConcept C6507245 @default.
• W2000998004 hasConcept C86803240 @default.
• W2000998004 hasConcept C95444343 @default.
• W2000998004 hasConceptScore W2000998004C12554922 @default.
• W2000998004 hasConceptScore W2000998004C129900496 @default.
• W2000998004 hasConceptScore W2000998004C142669718 @default.
• W2000998004 hasConceptScore W2000998004C147944092 @default.
• W2000998004 hasConceptScore W2000998004C1491633281 @default.
• W2000998004 hasConceptScore W2000998004C159985019 @default.
• W2000998004 hasConceptScore W2000998004C170493617 @default.
• W2000998004 hasConceptScore W2000998004C178790620 @default.
• W2000998004 hasConceptScore W2000998004C185592680 @default.
• W2000998004 hasConceptScore W2000998004C192562407 @default.
• W2000998004 hasConceptScore W2000998004C2775995422 @default.
• W2000998004 hasConceptScore W2000998004C2776041460 @default.
• W2000998004 hasConceptScore W2000998004C2778106830 @default.
• W2000998004 hasConceptScore W2000998004C2778540859 @default.
• W2000998004 hasConceptScore W2000998004C2779012151 @default.
• W2000998004 hasConceptScore W2000998004C537181965 @default.
• W2000998004 hasConceptScore W2000998004C55493867 @default.
• W2000998004 hasConceptScore W2000998004C6507245 @default.
• W2000998004 hasConceptScore W2000998004C86803240 @default.
• W2000998004 hasConceptScore W2000998004C95444343 @default.
• W2000998004 hasIssue "2" @default.
• W2000998004 hasLocation W20009980041 @default.
• W2000998004 hasLocation W20009980042 @default.
• W2000998004 hasLocation W20009980043 @default.
• W2000998004 hasLocation W20009980044 @default.
• W2000998004 hasOpenAccess W2000998004 @default.
• W2000998004 hasPrimaryLocation W20009980041 @default.

• next