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• W2000999320 abstract "Rat calvaria cells grown in culture for one week had properties of osteoblasts: a high content in alkaline phosphatase and a marked cyclic AMP response to parathyroid hormone (PTH). In short-term experiments, insulin-like growth factor I (IGF I) stimulated the incorporation of [14C] glucose into glycogen. When IGF I was present in the medium during 6 days the cell number increased slightly and there was a substantial, disproportionate rise in alkaline phosphatase activity of the cultures. Thus, IGF I stimulates growth, and in addition, and in contrast to other growth factors, mainly enhances differentiation of osteoblasts." @default.
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• W2000999320 date "1984-07-23" @default.
• W2000999320 modified "2023-09-25" @default.
• W2000999320 title "Insulin-like growth factor I supports differentiation of cultured osteoblast-like cells" @default.
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• W2000999320 doi "https://doi.org/10.1016/0014-5793(84)81015-7" @default.
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