FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001003604> ?p ?o ?g. }

• W2001003604 endingPage "605" @default.
• W2001003604 startingPage "600" @default.
• W2001003604 abstract "Delphinium nordhagenii belongs to family Ranunculaceae, it is widely found in tropical areas of Pakistan. Other species of Delphinium are reported as anticonvulsant and are traditionally used in the treatment of epilepsy. Delphinium nordhagenii is used by local healer in Pakistan but never used for scientific investigation as anticonvulsant. Thus, Delphinium nordhagenii was subjected to bioassay-guided fractionation and the most active fraction, i.e. DNS II acetone was chosen for further testing in the acute seizure models of epilepsy to study the antiepileptic potential in male mice. Different doses (60, 65 and 70 mg/kg, i.p.) of DNS II acetone fraction of Delphinium nordhagenii was administered 30 min prior the chemoconvulsant's injection in the male mice. Convulsive doses of chemoconvulsants (pentylenetetrazole 90 mg/kg, s.c. and picrotoxin 3.15 mg/kg, s.c.) were used. The mice were observed 45–90 min for the presence of seizures. Moreover, four different doses of DNS II (60, 65, 70 and 100 mg/kg, i.p.) were tested in the MES test. The DNS II acetone fraction of Delphinium nordhagenii has exhibited the anticonvulsant actions by preventing the seizures against PTZ- and picrotoxin-induced seizure as well as 100% seizure protection in MES test. The results are comparable with standard AEDs (diazepam 7.5 mg/kg, i.p. and phenytoin 20 mg/kg, i.p.). These findings suggest that the Delphinium nordhagenii possesses the anticonvulsant activity. Further analysis is needed to confirm the structure and target the extended activity profile." @default.
• W2001003604 created "2016-06-24" @default.
• W2001003604 creator A5003156018 @default.
• W2001003604 creator A5034612797 @default.
• W2001003604 creator A5044856027 @default.
• W2001003604 creator A5081164179 @default.
• W2001003604 creator A5086970012 @default.
• W2001003604 date "2010-04-01" @default.
• W2001003604 modified "2023-10-16" @default.
• W2001003604 title "Anticonvulsant activity of DNS II fraction in the acute seizure models" @default.
• W2001003604 cites W100576144 @default.
• W2001003604 cites W120683013 @default.
• W2001003604 cites W1547658095 @default.
• W2001003604 cites W1555962450 @default.
• W2001003604 cites W168945570 @default.
• W2001003604 cites W1968543162 @default.
• W2001003604 cites W1969648109 @default.
• W2001003604 cites W1970014384 @default.
• W2001003604 cites W1976354860 @default.
• W2001003604 cites W1987584839 @default.
• W2001003604 cites W1988098354 @default.
• W2001003604 cites W1989064578 @default.
• W2001003604 cites W1990545378 @default.
• W2001003604 cites W1997911152 @default.
• W2001003604 cites W1998249177 @default.
• W2001003604 cites W2007837436 @default.
• W2001003604 cites W2009014445 @default.
• W2001003604 cites W2021155136 @default.
• W2001003604 cites W2025616532 @default.
• W2001003604 cites W2037756052 @default.
• W2001003604 cites W2037793344 @default.
• W2001003604 cites W2037997999 @default.
• W2001003604 cites W2039721023 @default.
• W2001003604 cites W2041504470 @default.
• W2001003604 cites W2041907686 @default.
• W2001003604 cites W2042008454 @default.
• W2001003604 cites W2047744286 @default.
• W2001003604 cites W2051154442 @default.
• W2001003604 cites W2053356199 @default.
• W2001003604 cites W2067686370 @default.
• W2001003604 cites W2071224253 @default.
• W2001003604 cites W2081575009 @default.
• W2001003604 cites W2082488891 @default.
• W2001003604 cites W2087188787 @default.
• W2001003604 cites W2089821415 @default.
• W2001003604 cites W2093141934 @default.
• W2001003604 cites W2109899256 @default.
• W2001003604 cites W2110926310 @default.
• W2001003604 cites W2121413985 @default.
• W2001003604 cites W2136947638 @default.
• W2001003604 cites W2139593954 @default.
• W2001003604 cites W2155633484 @default.
• W2001003604 cites W2158562453 @default.
• W2001003604 cites W2265814058 @default.
• W2001003604 cites W2284224350 @default.
• W2001003604 cites W2323471917 @default.
• W2001003604 cites W2471904403 @default.
• W2001003604 cites W621907659 @default.
• W2001003604 cites W2154277990 @default.
• W2001003604 cites W2322970929 @default.
• W2001003604 doi "https://doi.org/10.1016/j.jep.2010.01.054" @default.
• W2001003604 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20138136" @default.
• W2001003604 hasPublicationYear "2010" @default.
• W2001003604 type Work @default.
• W2001003604 sameAs 2001003604 @default.
• W2001003604 citedByCount "10" @default.
• W2001003604 countsByYear W20010036042012 @default.
• W2001003604 countsByYear W20010036042013 @default.
• W2001003604 countsByYear W20010036042014 @default.
• W2001003604 countsByYear W20010036042015 @default.
• W2001003604 countsByYear W20010036042018 @default.
• W2001003604 countsByYear W20010036042019 @default.
• W2001003604 countsByYear W20010036042023 @default.
• W2001003604 crossrefType "journal-article" @default.
• W2001003604 hasAuthorship W2001003604A5003156018 @default.
• W2001003604 hasAuthorship W2001003604A5034612797 @default.
• W2001003604 hasAuthorship W2001003604A5044856027 @default.
• W2001003604 hasAuthorship W2001003604A5081164179 @default.
• W2001003604 hasAuthorship W2001003604A5086970012 @default.
• W2001003604 hasConcept C118552586 @default.
• W2001003604 hasConcept C126322002 @default.
• W2001003604 hasConcept C170493617 @default.
• W2001003604 hasConcept C185592680 @default.
• W2001003604 hasConcept C2775858608 @default.
• W2001003604 hasConcept C2776175493 @default.
• W2001003604 hasConcept C2776885963 @default.
• W2001003604 hasConcept C2778186239 @default.
• W2001003604 hasConcept C2778337148 @default.
• W2001003604 hasConcept C2778460930 @default.
• W2001003604 hasConcept C2779324764 @default.
• W2001003604 hasConcept C2779411416 @default.
• W2001003604 hasConcept C2781061982 @default.
• W2001003604 hasConcept C59822182 @default.
• W2001003604 hasConcept C71924100 @default.
• W2001003604 hasConcept C86803240 @default.
• W2001003604 hasConcept C98274493 @default.
• W2001003604 hasConceptScore W2001003604C118552586 @default.
• W2001003604 hasConceptScore W2001003604C126322002 @default.

• next