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- W2001004826 abstract "Intraperitoneal injection of epidermal growth factor into mice results in the appearance of multiple tyrosine-phosphorylated proteins in liver nuclei within minutes after administration. We have previously identified three of these proteins as Stat 1 alpha, Stat 1 beta (p91, p84), and Stat 3 (p89). In the present report we demonstrate that Stat 5 (p92), the recently described prolactin inducible transcription factor detected in mammary glands, is the major tyrosine-phosphorylated protein translocated to the nucleus in mouse liver in response to epidermal growth factor. Furthermore, gel-shift analysis and affinity purification revealed that Stat 5, Stat 1 alpha, and Stat 1 beta specifically bind to the prolactin inducible element upstream of the beta-casein promoter." @default.
- W2001004826 created "2016-06-24" @default.
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- W2001004826 date "1995-05-09" @default.
- W2001004826 modified "2023-09-26" @default.
- W2001004826 title "Epidermal growth factor induces the tyrosine phosphorylation and nuclear translocation of Stat 5 in mouse liver." @default.
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- W2001004826 doi "https://doi.org/10.1073/pnas.92.10.4215" @default.
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