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• W2001008031 abstract "Electrophysiological changes in basal ganglia neurons are hypothesized to underlie motor dysfunction in Parkinson's disease (PD). Previous results in head-restrained MPTP-treated non-human primates have suggested that increased bursting within the basal ganglia and related thalamic and cortical areas may be a hallmark of pathophysiological activity. In this study, we investigated whether there is increased bursting in substantia nigra pars reticulata (SNpr) output neurons in anesthetized and awake, head-restrained unilaterally lesioned 6-OHDA mice when compared to control mice. Confirming previous studies, we show that there are significant changes in the firing rate and pattern in SNpr neuron activity under urethane anesthesia. The regular firing pattern of control urethane-anesthetized SNpr neurons was not present in the 6-OHDA-lesioned group, as the latter neurons instead became phase locked with cortical slow wave activity (SWA). Next, we examined whether such robust electrophysiological changes between groups carried over to the awake state. SNpr neurons from both groups fired at much higher frequencies in the awake state than in the anesthetized state and surprisingly showed only modest changes between awake control and 6-OHDA groups. While there were no differences in firing rate between groups in the awake state, an increase in the coefficient of variation (CV) was observed in the 6-OHDA group. Contrary to the bursting hypothesis, this increased CV was not due to changes in bursting but was instead due to a mild increase in pausing. Together, these results suggest that differences in SNpr activity between control and 6-OHDA lesioned mice may be strongly influenced by changes in network activity during different arousal and behavioral states." @default.
• W2001008031 created "2016-06-24" @default.
• W2001008031 creator A5020227511 @default.
• W2001008031 creator A5077090898 @default.
• W2001008031 date "2015-03-01" @default.
• W2001008031 modified "2023-10-15" @default.
• W2001008031 title "Bursting activity of substantia nigra pars reticulata neurons in mouse parkinsonism in awake and anesthetized states" @default.
• W2001008031 cites W1516646705 @default.
• W2001008031 cites W1581585860 @default.
• W2001008031 cites W1589858513 @default.
• W2001008031 cites W1695871570 @default.
• W2001008031 cites W1756893006 @default.
• W2001008031 cites W1768450208 @default.
• W2001008031 cites W1832682301 @default.
• W2001008031 cites W1833314573 @default.
• W2001008031 cites W1877102286 @default.
• W2001008031 cites W1897507705 @default.
• W2001008031 cites W1905563481 @default.
• W2001008031 cites W1958547196 @default.
• W2001008031 cites W1965108138 @default.
• W2001008031 cites W1965628921 @default.
• W2001008031 cites W1965773704 @default.
• W2001008031 cites W1968261149 @default.
• W2001008031 cites W1968791710 @default.
• W2001008031 cites W1974260937 @default.
• W2001008031 cites W1982864501 @default.
• W2001008031 cites W1985934237 @default.
• W2001008031 cites W1987526284 @default.
• W2001008031 cites W1990454524 @default.
• W2001008031 cites W1991869255 @default.
• W2001008031 cites W1993576080 @default.
• W2001008031 cites W2000478038 @default.
• W2001008031 cites W2001630545 @default.
• W2001008031 cites W2004693301 @default.
• W2001008031 cites W2005674083 @default.
• W2001008031 cites W2009290984 @default.
• W2001008031 cites W2010648283 @default.
• W2001008031 cites W2014598495 @default.
• W2001008031 cites W2017063807 @default.
• W2001008031 cites W2017948121 @default.
• W2001008031 cites W2018191142 @default.
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• W2001008031 cites W2025687881 @default.
• W2001008031 cites W2026352136 @default.
• W2001008031 cites W2027274005 @default.
• W2001008031 cites W2034845144 @default.
• W2001008031 cites W2039381332 @default.
• W2001008031 cites W2041840285 @default.
• W2001008031 cites W2042420303 @default.
• W2001008031 cites W2046361830 @default.
• W2001008031 cites W2047575016 @default.
• W2001008031 cites W2051572005 @default.
• W2001008031 cites W2055180036 @default.
• W2001008031 cites W2059107223 @default.
• W2001008031 cites W2059650544 @default.
• W2001008031 cites W2060496651 @default.
• W2001008031 cites W2062028474 @default.
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• W2001008031 doi "https://doi.org/10.1016/j.nbd.2014.12.026" @default.
• W2001008031 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4406485" @default.
• W2001008031 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25576395" @default.
• W2001008031 hasPublicationYear "2015" @default.
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