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- W2001008105 abstract "Two dextran derivatives, fluorescein isothiocyanate-dextran (DT) and fluorescein isothiocyanate diethylaminoethyldextran (DE), were administered intranasally to study how the molecular weight and charge influence permeation through nasal mucosa in rabbits. These compounds were used as macromolecular models of water-soluble drugs. The concentration in plasma was determined using a high-performance liquid Chromatograph equipped with a fluorescence spectrometer by means of a fluorescein isothiocyanate-dextran derivative conjugate. The concentration of DT in plasma decreased as the molecular weight of DT increased. The administration of DE (molecular weight less than 10,000) resulted in a significant increase of the concentration of DE in plasma, compared with DT. The concentration of DE in plasma increased conversely to the molecular weight of DE." @default.
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- W2001008105 date "1989-01-01" @default.
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- W2001008105 title "Influence of molecular weight and charge on nasal absorption of dextran and DEAE-dextran in rabbits" @default.
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- W2001008105 doi "https://doi.org/10.1016/0378-5173(89)90148-8" @default.
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