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- W2001010264 abstract "Brain metastases are a significant source of morbidity and mortality in breast cancer patients with a positive status for human epidermal growth factor receptor 2 (HER2). While clinical benefit was reported for treatment of brain metastases with trastuzumab, preclinical results recently suggested that trastuzumab may radiosensitize breast cancer cell lines to ionizing radiation. We retrospectively assessed the use of trastuzumab concurrently with whole-brain radiotherapy (WBRT). From April 2001 to April 2007, 31 patients with brain metastases from HER2-positive breast cancer were referred for WBRT with concurrent trastuzumab. At the time of brain progression, median age was 55 years (range: 38 - 73 years) and all patients had a performance status of 0 - 2. Patients received trastuzumab 2 mg/kg weekly (n = 17) or 6 mg/kg repeated every 21 days (n = 14). In 26 patients, concurrent WBRT delivered 30 Gy in 10 daily fractions. In six patients, other fractionations were chosen because of either poor performance status or patients' convenience. Following WBRT, radiological responses were observed in 23 patients (74.2 %), including six patients (19.4 %) with complete radiological responses and 17 patients (54.8%) with partial radiological response. Clinical responses were observed in 27 patients (87.1 %). Median survival from the start of WBRT was 18 months (range: 2 to 65 months). Median time to brain progression was 10.5 months (range: 2 to 27 months). No grade 2 or more acute toxicity was observed. Our results suggest that trastuzumab may have a potential clinical impact with low toxicity concurrently with WBRT. Although promising, these preliminary data warrant further validation of trastuzumab as a radiosensitizer for WBRT in brain metastases from breast cancer in the setting of a clinical trial." @default.
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- W2001010264 date "2010-11-01" @default.
- W2001010264 modified "2023-09-26" @default.
- W2001010264 title "Whole Brain Radiotherapy with Concurrent Trastuzumab for Treatment of Brain Metastases in Breast Cancer Patients" @default.
- W2001010264 doi "https://doi.org/10.1016/j.ijrobp.2010.07.569" @default.
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