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- W2001010367 abstract "Serotonin plays a role in T cell activation, but there is no clear consensus of which of the 14 serotonergic receptors control this activations pathway. We have used a broad range of serotonergic receptor antagonists to define the functional involvement of these receptors governing the proliferation of primary T cells as well as in T cell lines. Our data shows that antagonism of the 5-HT1B receptor inhibits the proliferation of both human and murine primary helper T cells and of human helper T cell lines. As a whole, our data suggest that other serotonergic receptors may contribute to the proliferative signals, but the 5-HT1B receptor plays the most dominant role." @default.
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- W2001010367 date "2006-12-01" @default.
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- W2001010367 title "5-HT1B receptors play a prominent role in the proliferation of T-lymphocytes" @default.
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- W2001010367 doi "https://doi.org/10.1016/j.jneuroim.2006.08.004" @default.
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