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- W2001018081 abstract "Phosphatidylcholines (PCs) having an acyl chain with a 2,4-dienal terminal are expected to be important bioactive compounds formed during lipid peroxidation in vivo. However, they have not been isolated from biological tissues. Here we used electrospray mass spectroscopy to investigate whether a high autoxidative instability may contribute to the difficulty in detecting one such compound, 13-oxo-9,11-tridecadienoyl PC (OTDA–PC, 1). Although we found that pure, synthetic OTDA–PC was very stable, OTDA–PC formed during the decomposition of a PC bearing the 13-hydroperoxide of α-linolenic acid (PC–LNA–OOH, 2) was readily converted (i) anaerobically to its corresponding acid PC, 13-carboxy-9,11-tridecadienoyl PC, 3; (ii) aerobically to other bioactive aldehyde (or acid) PC species that have been detected in atherosclerotic tissues. We attribute the high oxidative instability of OTDA–PC to a high vulnerability of its carbonyl hydrogen [H−C(O)R] to abstraction by lipid-derived radicals, and propose mechanisms for its conversion to the other oxidised PC species (vide supra)." @default.
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- W2001018081 date "2004-08-01" @default.
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- W2001018081 title "The rapid oxidative degradation of a phosphatidylcholine bearing an oxidatively modified acyl chain with a 2,4-dienal terminal" @default.
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- W2001018081 doi "https://doi.org/10.1016/j.chemphyslip.2004.04.004" @default.
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