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• W2001019228 startingPage "10925" @default.
• W2001019228 abstract "Stressed mammalian cells up-regulate heme oxygenase 1 (Hmox1; EC 1.14.99.3), which catabolizes heme to biliverdin, carbon monoxide, and free iron. To assess the potential role of Hmox1 in cellular antioxidant defense, we analyzed the responses of cells from mice lacking functional Hmox1 to oxidative challenges. Cultured Hmox1(-/-) embryonic fibroblasts demonstrated high oxygen free radical production when exposed to hemin, hydrogen peroxide, paraquat, or cadmium chloride, and they were hypersensitive to cytotoxicity caused by hemin and hydrogen peroxide. Furthermore, young adult Hmox1(-/-) mice were vulnerable to mortality and hepatic necrosis when challenged with endotoxin. Our in vitro and in vivo results provide genetic evidence that up-regulation of Hmox1 serves as an adaptive mechanism to protect cells from oxidative damage during stress." @default.
• W2001019228 created "2016-06-24" @default.
• W2001019228 creator A5038557565 @default.
• W2001019228 creator A5082015658 @default.
• W2001019228 date "1997-09-30" @default.
• W2001019228 modified "2023-10-11" @default.
• W2001019228 title "Reduced stress defense in heme oxygenase 1-deficient cells" @default.
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• W2001019228 doi "https://doi.org/10.1073/pnas.94.20.10925" @default.
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