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• W2001023145 abstract "Depression is a serious and burdensome illness. Although selective serotonin reuptake inhibitors (SSRIs) have improved safety and tolerability of antidepressant treatment efficacy, the delay in the onset of action have not been improved. There is evidence to suggest that the delay in onset of therapeutic activity is a function of the drugs, rather than the disease. This suggests that research into the biological characteristics of depression and its treatments may yield faster-acting antidepressants. Emerging evidence from clinical studies with mirtazapine, venlafaxine and SSRI augmentation with pindolol suggests that these treatments may relieve antidepressant symptoms more rapidly than SSRIs. The putative mechanism of action of faster-acting antidepressant strategies presented here purports that conventional antidepressants acutely increase the availability of serotonin (5-hydroxytryptamine, 5-HT) or noradrenaline (NA), preferentially at their cell body level, which triggers negative feedback mechanisms. After continued stimulation, these feedback mechanisms become desensitised and the enhanced 5-HT availability is able to enhance 5-HT and/or NA neurotransmission. Putative fast-onset antidepressants, on the other hand, may uncouple such feedback control mechanisms and enhance 5-HT and/or NA neurotransmission more rapidly. Further studies are required to characterise in detail the interactions between NA and 5-HT systems and to definitively establish the early onset of candidate antidepressants such as mirtazapine, venlafaxine and pindolol augmentation." @default.
• W2001023145 created "2016-06-24" @default.
• W2001023145 creator A5002538047 @default.
• W2001023145 date "2003-03-01" @default.
• W2001023145 modified "2023-10-08" @default.
• W2001023145 title "The pharmacology of putative early-onset antidepressant strategies" @default.
• W2001023145 cites W1483255595 @default.
• W2001023145 cites W1963775706 @default.
• W2001023145 cites W1965641144 @default.
• W2001023145 cites W1974703596 @default.
• W2001023145 cites W1976610164 @default.
• W2001023145 cites W1979293025 @default.
• W2001023145 cites W1981518746 @default.
• W2001023145 cites W1981581530 @default.
• W2001023145 cites W1983160636 @default.
• W2001023145 cites W1986197012 @default.
• W2001023145 cites W1987446423 @default.
• W2001023145 cites W1990917297 @default.
• W2001023145 cites W1992378184 @default.
• W2001023145 cites W1994300507 @default.
• W2001023145 cites W1996034110 @default.
• W2001023145 cites W1999522182 @default.
• W2001023145 cites W2001919680 @default.
• W2001023145 cites W2002184547 @default.
• W2001023145 cites W2004852769 @default.
• W2001023145 cites W2010069094 @default.
• W2001023145 cites W2010942461 @default.
• W2001023145 cites W2012975250 @default.
• W2001023145 cites W2017768664 @default.
• W2001023145 cites W2019823288 @default.
• W2001023145 cites W2021012303 @default.
• W2001023145 cites W2023437958 @default.
• W2001023145 cites W2027011765 @default.
• W2001023145 cites W2036527411 @default.
• W2001023145 cites W2044222412 @default.
• W2001023145 cites W2045020364 @default.
• W2001023145 cites W2046514269 @default.
• W2001023145 cites W2056513437 @default.
• W2001023145 cites W2060727938 @default.
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• W2001023145 cites W2067800689 @default.
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• W2001023145 cites W2072341886 @default.
• W2001023145 cites W2075312309 @default.
• W2001023145 cites W2079669517 @default.
• W2001023145 cites W2080230064 @default.
• W2001023145 cites W2082154403 @default.
• W2001023145 cites W2085525314 @default.
• W2001023145 cites W2091428501 @default.
• W2001023145 cites W2094034945 @default.
• W2001023145 cites W2098307510 @default.
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• W2001023145 cites W2121878996 @default.
• W2001023145 cites W2128478444 @default.
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• W2001023145 doi "https://doi.org/10.1016/s0924-977x(02)00173-6" @default.
• W2001023145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12650947" @default.
• W2001023145 hasPublicationYear "2003" @default.
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