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- W2001026345 abstract "The combined use of a pore-forming amphiphile, 1 (derived from lysine, cholic acid, and spermine), and thermally sensitive liposomes (made from 1,2-dipalmitoyl-sn-glycero-3-phosphocholine, DPPC) to create thermally gated liposomes (TGLs) has been demonstrated. Thus, at temperatures that lie above the gel to liquid-crystalline phase transition temperature of DPPC (i.e., 41 degrees C), 1 creates pores within DPPC membranes through which entrapped aqueous solutes, such as carboxyfluorescein, can readily pass. Below this temperature, efflux rates are greatly reduced. The potential of TGLs as devices for the targeted delivery of therapeutic agents is briefly discussed." @default.
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- W2001026345 date "2005-04-15" @default.
- W2001026345 modified "2023-10-09" @default.
- W2001026345 title "Thermally Gated Liposomes" @default.
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- W2001026345 doi "https://doi.org/10.1021/ja0513584" @default.
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