FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001029339> ?p ?o ?g. }

• W2001029339 endingPage "784" @default.
• W2001029339 startingPage "777" @default.
• W2001029339 abstract "OBJECTIVE: To estimate the efficacy of isotretinoin for prevention of progression of low-grade squamous intraepithelial lesions (SIL) of the cervix to high-grade lesions or invasive cervical cancer; to estimate the regression rate of low-grade SIL with isotretinoin and the toxicity of isotretinoin in this setting; and to correlate serum CD4 levels with progression of low-grade SIL. METHODS: A randomized, phase III, observation-controlled, multicenter trial was performed in which 117 human immunodeficiency virus (HIV)-positive women with low-grade SIL of the cervix received either oral isotretinoin at 0.5 mg/kg per day for 6 months or observation. Papanicolaou smears and colposcopy/biopsy were done at regular intervals during follow-up. The primary endpoint was progression to high-grade SIL or cervical cancer. RESULTS: Twenty-one of 102 women (20.6%) completing follow-up experienced progression to high-grade SIL, 13 in the observation group and eight in the isotretinoin group. This difference was not significant (P = .29). No cases of invasive cancer were seen. Baseline CD4 levels were lower than anticipated (median 329 cells/mm3), but not associated with time to progression (P = .36). Most subjects (63 of 102, 61.7%) used highly active antiretroviral therapy. Subjects under age 30 were more likely to progress than those older than 30 (P = .046). CONCLUSION: Isotretinoin was not associated with longer time to progression of low-grade SIL. This appears to be a chronic condition in HIV-positive women, with a low risk of progression and significant rate of resolution. As in the general population, observation without excisional therapy may be appropriate for HIV-positive women with low-grade SIL." @default.
• W2001029339 created "2016-06-24" @default.
• W2001029339 creator A5013892260 @default.
• W2001029339 creator A5034828137 @default.
• W2001029339 creator A5052412044 @default.
• W2001029339 creator A5055767678 @default.
• W2001029339 creator A5066667500 @default.
• W2001029339 creator A5078758111 @default.
• W2001029339 date "2002-05-01" @default.
• W2001029339 modified "2023-09-30" @default.
• W2001029339 title "Isotretinoin for low-grade cervical dysplasia in human immunodeficiency virus-infected women1 , *1" @default.
• W2001029339 cites W1575298979 @default.
• W2001029339 cites W1586962881 @default.
• W2001029339 cites W1976380392 @default.
• W2001029339 cites W1979300931 @default.
• W2001029339 cites W1996772943 @default.
• W2001029339 cites W2005124378 @default.
• W2001029339 cites W2006582248 @default.
• W2001029339 cites W2012603529 @default.
• W2001029339 cites W2026417341 @default.
• W2001029339 cites W2033344303 @default.
• W2001029339 cites W2047753655 @default.
• W2001029339 cites W2053238499 @default.
• W2001029339 cites W2057196885 @default.
• W2001029339 cites W2059707463 @default.
• W2001029339 cites W206105818 @default.
• W2001029339 cites W2072043459 @default.
• W2001029339 cites W2074393823 @default.
• W2001029339 cites W2081769719 @default.
• W2001029339 cites W2089319896 @default.
• W2001029339 cites W2091259243 @default.
• W2001029339 cites W2091823964 @default.
• W2001029339 cites W2093630931 @default.
• W2001029339 cites W2116258000 @default.
• W2001029339 cites W2122580165 @default.
• W2001029339 cites W2123328011 @default.
• W2001029339 cites W2127053561 @default.
• W2001029339 cites W2127151679 @default.
• W2001029339 cites W2150930737 @default.
• W2001029339 cites W2263204859 @default.
• W2001029339 cites W2282363704 @default.
• W2001029339 cites W2325460440 @default.
• W2001029339 doi "https://doi.org/10.1016/s0029-7844(02)01949-x" @default.
• W2001029339 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11978287" @default.
• W2001029339 hasPublicationYear "2002" @default.
• W2001029339 type Work @default.
• W2001029339 sameAs 2001029339 @default.
• W2001029339 citedByCount "17" @default.
• W2001029339 countsByYear W20010293392013 @default.
• W2001029339 countsByYear W20010293392015 @default.
• W2001029339 countsByYear W20010293392022 @default.
• W2001029339 crossrefType "journal-article" @default.
• W2001029339 hasAuthorship W2001029339A5013892260 @default.
• W2001029339 hasAuthorship W2001029339A5034828137 @default.
• W2001029339 hasAuthorship W2001029339A5052412044 @default.
• W2001029339 hasAuthorship W2001029339A5055767678 @default.
• W2001029339 hasAuthorship W2001029339A5066667500 @default.
• W2001029339 hasAuthorship W2001029339A5078758111 @default.
• W2001029339 hasConcept C121608353 @default.
• W2001029339 hasConcept C126322002 @default.
• W2001029339 hasConcept C16005928 @default.
• W2001029339 hasConcept C2775894508 @default.
• W2001029339 hasConcept C2776117191 @default.
• W2001029339 hasConcept C2776285725 @default.
• W2001029339 hasConcept C2777673923 @default.
• W2001029339 hasConcept C2777740455 @default.
• W2001029339 hasConcept C2778220009 @default.
• W2001029339 hasConcept C29456083 @default.
• W2001029339 hasConcept C71924100 @default.
• W2001029339 hasConcept C90924648 @default.
• W2001029339 hasConceptScore W2001029339C121608353 @default.
• W2001029339 hasConceptScore W2001029339C126322002 @default.
• W2001029339 hasConceptScore W2001029339C16005928 @default.
• W2001029339 hasConceptScore W2001029339C2775894508 @default.
• W2001029339 hasConceptScore W2001029339C2776117191 @default.
• W2001029339 hasConceptScore W2001029339C2776285725 @default.
• W2001029339 hasConceptScore W2001029339C2777673923 @default.
• W2001029339 hasConceptScore W2001029339C2777740455 @default.
• W2001029339 hasConceptScore W2001029339C2778220009 @default.
• W2001029339 hasConceptScore W2001029339C29456083 @default.
• W2001029339 hasConceptScore W2001029339C71924100 @default.
• W2001029339 hasConceptScore W2001029339C90924648 @default.
• W2001029339 hasIssue "5" @default.
• W2001029339 hasLocation W20010293391 @default.
• W2001029339 hasLocation W20010293392 @default.
• W2001029339 hasOpenAccess W2001029339 @default.
• W2001029339 hasPrimaryLocation W20010293391 @default.
• W2001029339 hasRelatedWork W1981773266 @default.
• W2001029339 hasRelatedWork W2025105594 @default.
• W2001029339 hasRelatedWork W2184317297 @default.
• W2001029339 hasRelatedWork W2514884906 @default.
• W2001029339 hasRelatedWork W2888045684 @default.
• W2001029339 hasRelatedWork W3011191626 @default.
• W2001029339 hasRelatedWork W3025239604 @default.
• W2001029339 hasRelatedWork W3213770797 @default.
• W2001029339 hasRelatedWork W4210690965 @default.
• W2001029339 hasRelatedWork W2186662502 @default.
• W2001029339 hasVolume "99" @default.

• next