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• W2001034290 abstract "ITB (6-(p-bromophenyl)amino-7-(p-chlorophenyl)indazolo[2′,3′:1,5]-1,2,4-triazolo[4,3-a]-1,3,5-benzotriazepine) is a novel inhibitor of cyclo-oxygenase-2 (COX-2) with antiinflammatory activity in animal models. In the present study, we investigated the effect of this compound on the production of catabolic or antiinflammatory mediators in osteoarthritis (OA) cartilage. In OA cartilage explants, ITB inhibited the production of prostaglandin E2 (PGE2), tumour necrosis factor-α (TNF-α) and matrix metalloproteinase-13 (MMP-13) in a concentration-dependent manner, whereas nitrite was partially reduced. On the contrary, ITB increased the production of interleukin (IL)-10 and the expression of heme oxygenase-1 (HO-1). ITB inhibited the production of catabolic mediators at concentrations able to increase IL-10 and HO-1 in OA cartilage, suggesting that this compound may be useful in the prevention of cartilage degradation." @default.
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• W2001034290 date "2004-08-01" @default.
• W2001034290 modified "2023-10-14" @default.
• W2001034290 title "A novel cyclo-oxygenase-2 inhibitor modulates catabolic and antiinflammatory mediators in osteoarthritis" @default.
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• W2001034290 doi "https://doi.org/10.1016/j.bcp.2004.03.038" @default.
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