FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001040966> ?p ?o ?g. }

• W2001040966 endingPage "e0123965" @default.
• W2001040966 startingPage "e0123965" @default.
• W2001040966 abstract "The Dlg1 gene encodes a member of the MAGUK protein family involved in the polarization of epithelial cells. Null mutant mice for the Dlg1 gene (Dlg1-/- mice) exhibit respiratory failure and cyanosis, and die soon after birth. However, the cause of this neonatal lethality has not been determined. In the present study, we further examined Dlg1-/- mice and found severe defects in the cardiovascular system, including ventricular septal defect, persistent truncus arteriosus, and double outlet right ventricle, which would cause the neonatal lethality. These cardiovascular phenotypes resemble those of mutant mice lacking planar cell polarity (PCP) genes and support a recent notion that DLG1 is involved in the PCP pathway. We assessed the degree of involvement of DLG1 in the development of other organs, as the cochlea, intestine, and skeleton, in which PCP signaling has been suggested to play a role. In the organ of Corti, tissue elongation was inhibited accompanied by disorganized arrangement of the hair cell rows, while the orientation of the stereocilia bundle was normal. In the sternum, cleft sternum, abnormal calcification pattern of cartilage, and disorganization of chondrocytes were observed. Furthermore, shortening of the intestine, sternum, and long bones of the limbs was observed. These phenotypes of Dlg1-/- mice involving cellular disorganization and insufficient tissue elongation strongly suggest a defect in the convergent extension movements in these mice. Thus, our present results provide a possibility that DLG1 is particularly required for convergent extension among PCP signaling-dependent processes." @default.
• W2001040966 created "2016-06-24" @default.
• W2001040966 creator A5001371042 @default.
• W2001040966 creator A5006196287 @default.
• W2001040966 creator A5008141081 @default.
• W2001040966 creator A5012741880 @default.
• W2001040966 creator A5025133470 @default.
• W2001040966 creator A5038285053 @default.
• W2001040966 creator A5045092813 @default.
• W2001040966 creator A5070289694 @default.
• W2001040966 creator A5078720265 @default.
• W2001040966 creator A5079836606 @default.
• W2001040966 date "2015-04-10" @default.
• W2001040966 modified "2023-09-30" @default.
• W2001040966 title "Requirement of DLG1 for Cardiovascular Development and Tissue Elongation during Cochlear, Enteric, and Skeletal Development: Possible Role in Convergent Extension" @default.
• W2001040966 cites W1547150431 @default.
• W2001040966 cites W1601726131 @default.
• W2001040966 cites W1931060259 @default.
• W2001040966 cites W1970063220 @default.
• W2001040966 cites W1970451927 @default.
• W2001040966 cites W1973180710 @default.
• W2001040966 cites W1973537879 @default.
• W2001040966 cites W1975709809 @default.
• W2001040966 cites W1978713117 @default.
• W2001040966 cites W1987537120 @default.
• W2001040966 cites W1987863854 @default.
• W2001040966 cites W1992644684 @default.
• W2001040966 cites W1998166790 @default.
• W2001040966 cites W2001716294 @default.
• W2001040966 cites W2001767250 @default.
• W2001040966 cites W2002027085 @default.
• W2001040966 cites W2009611668 @default.
• W2001040966 cites W2011317223 @default.
• W2001040966 cites W2012708732 @default.
• W2001040966 cites W2013294539 @default.
• W2001040966 cites W2014543214 @default.
• W2001040966 cites W2015766782 @default.
• W2001040966 cites W2031842244 @default.
• W2001040966 cites W2037389941 @default.
• W2001040966 cites W2041850471 @default.
• W2001040966 cites W2043912973 @default.
• W2001040966 cites W2045751117 @default.
• W2001040966 cites W2052217366 @default.
• W2001040966 cites W2052282754 @default.
• W2001040966 cites W2053797631 @default.
• W2001040966 cites W2053958751 @default.
• W2001040966 cites W2066831641 @default.
• W2001040966 cites W2068004733 @default.
• W2001040966 cites W2069126410 @default.
• W2001040966 cites W2075217649 @default.
• W2001040966 cites W2085121027 @default.
• W2001040966 cites W2085252478 @default.
• W2001040966 cites W2088028188 @default.
• W2001040966 cites W2090071382 @default.
• W2001040966 cites W2095430101 @default.
• W2001040966 cites W2097375811 @default.
• W2001040966 cites W2100706309 @default.
• W2001040966 cites W2101625485 @default.
• W2001040966 cites W2103978268 @default.
• W2001040966 cites W2123179372 @default.
• W2001040966 cites W2123290887 @default.
• W2001040966 cites W2128315635 @default.
• W2001040966 cites W2140577425 @default.
• W2001040966 cites W2145526270 @default.
• W2001040966 cites W2146117781 @default.
• W2001040966 cites W2161555795 @default.
• W2001040966 cites W2165431561 @default.
• W2001040966 cites W2166296674 @default.
• W2001040966 cites W2171214418 @default.
• W2001040966 doi "https://doi.org/10.1371/journal.pone.0123965" @default.
• W2001040966 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4393223" @default.
• W2001040966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25860837" @default.
• W2001040966 hasPublicationYear "2015" @default.
• W2001040966 type Work @default.
• W2001040966 sameAs 2001040966 @default.
• W2001040966 citedByCount "16" @default.
• W2001040966 countsByYear W20010409662016 @default.
• W2001040966 countsByYear W20010409662018 @default.
• W2001040966 countsByYear W20010409662019 @default.
• W2001040966 countsByYear W20010409662021 @default.
• W2001040966 countsByYear W20010409662022 @default.
• W2001040966 countsByYear W20010409662023 @default.
• W2001040966 crossrefType "journal-article" @default.
• W2001040966 hasAuthorship W2001040966A5001371042 @default.
• W2001040966 hasAuthorship W2001040966A5006196287 @default.
• W2001040966 hasAuthorship W2001040966A5008141081 @default.
• W2001040966 hasAuthorship W2001040966A5012741880 @default.
• W2001040966 hasAuthorship W2001040966A5025133470 @default.
• W2001040966 hasAuthorship W2001040966A5038285053 @default.
• W2001040966 hasAuthorship W2001040966A5045092813 @default.
• W2001040966 hasAuthorship W2001040966A5070289694 @default.
• W2001040966 hasAuthorship W2001040966A5078720265 @default.
• W2001040966 hasAuthorship W2001040966A5079836606 @default.
• W2001040966 hasBestOaLocation W20010409661 @default.
• W2001040966 hasConcept C104317684 @default.
• W2001040966 hasConcept C105702510 @default.
• W2001040966 hasConcept C127716648 @default.
• W2001040966 hasConcept C129536746 @default.

• next