Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001040994> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2001040994 abstract "Abstract Narcotic analgesics have been shown to be accumulated in cerebral cortical slices by a process having the characteristics of an active transport system. In addition, diffusion and binding contributed to the total uptake of the analgesics into brain slices. The total uptake of dihydromorphine (1 × 10 −6 M in medium) was found to reach steady state equilibrium in 30 min at 37° with a maximum tissue to medium concentration ratio ( T M ) of 2.3. Accumulation in vitro of the narcotic analgesics in brain differed from their accumulation in the kidney and in the choroid plexus in that there was a lower ( T M ) ratio at equilibrium for brain and the uptake by brain was not inhibited by quaternary organic bases. The narcotic analgesic antagonist, nalorphine, consistently depressed the uptake of dihydromorphine in a competitive manner." @default.
- W2001040994 created "2016-06-24" @default.
- W2001040994 creator A5004785159 @default.
- W2001040994 creator A5041655282 @default.
- W2001040994 date "1968-08-01" @default.
- W2001040994 modified "2023-09-27" @default.
- W2001040994 title "Active uptake of dihydromorphine and other narcotic analgesics by cerebral cortical slices" @default.
- W2001040994 cites W1023328272 @default.
- W2001040994 cites W1852547835 @default.
- W2001040994 cites W1856553378 @default.
- W2001040994 cites W1893417353 @default.
- W2001040994 cites W1923803416 @default.
- W2001040994 cites W1925620438 @default.
- W2001040994 cites W1928053399 @default.
- W2001040994 cites W1976209926 @default.
- W2001040994 cites W2013380188 @default.
- W2001040994 cites W2054979333 @default.
- W2001040994 cites W2082597223 @default.
- W2001040994 cites W2085790414 @default.
- W2001040994 cites W2105868755 @default.
- W2001040994 cites W2146270787 @default.
- W2001040994 cites W2205753780 @default.
- W2001040994 cites W2265862139 @default.
- W2001040994 cites W2268153384 @default.
- W2001040994 cites W2280725675 @default.
- W2001040994 cites W2409332539 @default.
- W2001040994 cites W2419322002 @default.
- W2001040994 doi "https://doi.org/10.1016/0006-2952(68)90215-3" @default.
- W2001040994 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/5672816" @default.
- W2001040994 hasPublicationYear "1968" @default.
- W2001040994 type Work @default.
- W2001040994 sameAs 2001040994 @default.
- W2001040994 citedByCount "20" @default.
- W2001040994 crossrefType "journal-article" @default.
- W2001040994 hasAuthorship W2001040994A5004785159 @default.
- W2001040994 hasAuthorship W2001040994A5041655282 @default.
- W2001040994 hasBestOaLocation W20010409942 @default.
- W2001040994 hasConcept C185592680 @default.
- W2001040994 hasConcept C2775849661 @default.
- W2001040994 hasConcept C2777389121 @default.
- W2001040994 hasConcept C2780820201 @default.
- W2001040994 hasConcept C2910783051 @default.
- W2001040994 hasConcept C42219234 @default.
- W2001040994 hasConcept C508975757 @default.
- W2001040994 hasConcept C71924100 @default.
- W2001040994 hasConcept C98274493 @default.
- W2001040994 hasConceptScore W2001040994C185592680 @default.
- W2001040994 hasConceptScore W2001040994C2775849661 @default.
- W2001040994 hasConceptScore W2001040994C2777389121 @default.
- W2001040994 hasConceptScore W2001040994C2780820201 @default.
- W2001040994 hasConceptScore W2001040994C2910783051 @default.
- W2001040994 hasConceptScore W2001040994C42219234 @default.
- W2001040994 hasConceptScore W2001040994C508975757 @default.
- W2001040994 hasConceptScore W2001040994C71924100 @default.
- W2001040994 hasConceptScore W2001040994C98274493 @default.
- W2001040994 hasLocation W20010409941 @default.
- W2001040994 hasLocation W20010409942 @default.
- W2001040994 hasLocation W20010409943 @default.
- W2001040994 hasOpenAccess W2001040994 @default.
- W2001040994 hasPrimaryLocation W20010409941 @default.
- W2001040994 hasRelatedWork W119136277 @default.
- W2001040994 hasRelatedWork W1974605788 @default.
- W2001040994 hasRelatedWork W1994156920 @default.
- W2001040994 hasRelatedWork W2013514526 @default.
- W2001040994 hasRelatedWork W2109572296 @default.
- W2001040994 hasRelatedWork W2136300870 @default.
- W2001040994 hasRelatedWork W2376368846 @default.
- W2001040994 hasRelatedWork W2474332700 @default.
- W2001040994 hasRelatedWork W4289986101 @default.
- W2001040994 hasRelatedWork W169474437 @default.
- W2001040994 isParatext "false" @default.
- W2001040994 isRetracted "false" @default.
- W2001040994 magId "2001040994" @default.
- W2001040994 workType "article" @default.