FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001047327> ?p ?o ?g. }

• W2001047327 endingPage "313" @default.
• W2001047327 startingPage "303" @default.
• W2001047327 abstract "Cochlear implants electrically stimulate residual spiral ganglion neurons (SGNs) to provide auditory cues for the severe-profoundly deaf. However, SGNs gradually degenerate following cochlear hair cell loss, leaving fewer neurons available for stimulation. Providing an exogenous supply of neurotrophins (NTs) has been shown to prevent SGN degeneration, and when combined with chronic intracochlear electrical stimulation (ES) following a short period of deafness (5 days), may also promote the formation of new neurons. The present study assessed the histopathological response of guinea pig cochleae treated with NTs (brain-derived neurotrophic factor and neurotrophin-3) with and without ES over a four week period, initiated two weeks after deafening. Results were compared to both NT alone and artificial perilymph (AP) treated animals. AP/ES treated animals exhibited no evidence of SGN rescue compared with untreated deafened controls. In contrast, NT administration showed a significant SGN rescue effect in the lower and middle cochlear turns (two-way ANOVA, p < 0.05) compared with AP-treated control animals. ES in combination with NT did not enhance SGN survival compared with NT alone. SGN function was assessed by measuring electrically-evoked auditory brainstem response (EABR) thresholds. EABR thresholds following NT treatment were significantly lower than animals treated with AP (two-way ANOVA, p = 0.033). Finally, the potential for induced neurogenesis following the combined treatment was investigated using a marker of DNA synthesis. However, no evidence of neurogenesis was observed in the SGN population. The results indicate that chronic NT delivery to the cochlea may be beneficial to cochlear implant patients by increasing the number of viable SGNs and decreasing activation thresholds compared to chronic ES alone." @default.
• W2001047327 created "2016-06-24" @default.
• W2001047327 creator A5018325827 @default.
• W2001047327 creator A5042579996 @default.
• W2001047327 creator A5077899797 @default.
• W2001047327 creator A5078011681 @default.
• W2001047327 date "2011-12-01" @default.
• W2001047327 modified "2023-10-16" @default.
• W2001047327 title "Spiral ganglion neuron survival and function in the deafened cochlea following chronic neurotrophic treatment" @default.
• W2001047327 cites W1545898285 @default.
• W2001047327 cites W1644197639 @default.
• W2001047327 cites W1699641386 @default.
• W2001047327 cites W1963627849 @default.
• W2001047327 cites W1964000981 @default.
• W2001047327 cites W1971972567 @default.
• W2001047327 cites W1973459013 @default.
• W2001047327 cites W1974113951 @default.
• W2001047327 cites W1978338397 @default.
• W2001047327 cites W1983725263 @default.
• W2001047327 cites W1985808169 @default.
• W2001047327 cites W1986131585 @default.
• W2001047327 cites W1993099172 @default.
• W2001047327 cites W1995894734 @default.
• W2001047327 cites W1999633987 @default.
• W2001047327 cites W2003863108 @default.
• W2001047327 cites W2004303128 @default.
• W2001047327 cites W2006904223 @default.
• W2001047327 cites W2008803709 @default.
• W2001047327 cites W2011814418 @default.
• W2001047327 cites W2019108060 @default.
• W2001047327 cites W2019255057 @default.
• W2001047327 cites W2025657276 @default.
• W2001047327 cites W2033448202 @default.
• W2001047327 cites W2038967660 @default.
• W2001047327 cites W2040588681 @default.
• W2001047327 cites W2044015089 @default.
• W2001047327 cites W2044483083 @default.
• W2001047327 cites W2045345899 @default.
• W2001047327 cites W2046046710 @default.
• W2001047327 cites W2046610720 @default.
• W2001047327 cites W2048326843 @default.
• W2001047327 cites W2052927503 @default.
• W2001047327 cites W2058359348 @default.
• W2001047327 cites W2061820614 @default.
• W2001047327 cites W2069855517 @default.
• W2001047327 cites W2071827440 @default.
• W2001047327 cites W2076669076 @default.
• W2001047327 cites W2078683084 @default.
• W2001047327 cites W2079319002 @default.
• W2001047327 cites W2081612934 @default.
• W2001047327 cites W2082999381 @default.
• W2001047327 cites W2087129686 @default.
• W2001047327 cites W2088611017 @default.
• W2001047327 cites W2090872390 @default.
• W2001047327 cites W2094063643 @default.
• W2001047327 cites W2094663849 @default.
• W2001047327 cites W2094899800 @default.
• W2001047327 cites W2095148197 @default.
• W2001047327 cites W2096560916 @default.
• W2001047327 cites W2098537456 @default.
• W2001047327 cites W2099181688 @default.
• W2001047327 cites W2099908130 @default.
• W2001047327 cites W2101414734 @default.
• W2001047327 cites W2105086774 @default.
• W2001047327 cites W2105564866 @default.
• W2001047327 cites W2122962129 @default.
• W2001047327 cites W2143374954 @default.
• W2001047327 cites W2152933007 @default.
• W2001047327 cites W2157252680 @default.
• W2001047327 cites W2160529976 @default.
• W2001047327 cites W2161918459 @default.
• W2001047327 cites W2162786182 @default.
• W2001047327 cites W2166637550 @default.
• W2001047327 cites W2171161097 @default.
• W2001047327 cites W2329587949 @default.
• W2001047327 cites W2416026395 @default.
• W2001047327 cites W2417491271 @default.
• W2001047327 cites W4243038715 @default.
• W2001047327 doi "https://doi.org/10.1016/j.heares.2011.06.007" @default.
• W2001047327 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3205216" @default.
• W2001047327 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21762764" @default.
• W2001047327 hasPublicationYear "2011" @default.
• W2001047327 type Work @default.
• W2001047327 sameAs 2001047327 @default.
• W2001047327 citedByCount "65" @default.
• W2001047327 countsByYear W20010473272012 @default.
• W2001047327 countsByYear W20010473272013 @default.
• W2001047327 countsByYear W20010473272014 @default.
• W2001047327 countsByYear W20010473272015 @default.
• W2001047327 countsByYear W20010473272016 @default.
• W2001047327 countsByYear W20010473272017 @default.
• W2001047327 countsByYear W20010473272018 @default.
• W2001047327 countsByYear W20010473272019 @default.
• W2001047327 countsByYear W20010473272020 @default.
• W2001047327 countsByYear W20010473272021 @default.
• W2001047327 countsByYear W20010473272022 @default.
• W2001047327 countsByYear W20010473272023 @default.
• W2001047327 crossrefType "journal-article" @default.

• next