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- W2001053169 abstract "Two childhood cases are reported of peripheral T-cell lymphoma; the neoplastic cells expressed activated CD8 (T8) phenotype and contained Epstein-Barr viral (EBV) DNA. Both patients had an aggressive and rapid clinical course despite chemotherapy. Elevated titers of antibodies to EBV-viral capsid antigen (>640) and early antigen (>10) were found in both patients. Histology revealed pleomorphic immunoblastic lymphoma with extensive necrosis in one case and an angioimmunoblastic lymphadenopathy-like pattern containing Reed-Sternberg-like giant cells in the other. Southern blot hybridization studies showed clonal rearrangement of the T-cell-receptor beta gene in both cases, and a cytogenetic study on one case revealed clonal structural abnormality involving chromosomes 1, 6, 7, 10, and 19. Analysis of the tumor DNA showed a high copy number of EBV genome per cell compared with that of Raji and Marmoset B 95.8 lines; the study for human T-cell leukemia virus type I was negative. the EBV genome was found by in situ hybridization in the tumor nuclei in both cases. in addition to Burkitt's lymphoma, T-cell lymphoma of the helper phenotype, and Hodgkin's disease, EBV can contribute to the development of CD8-positive aggressive T-cell lymphoma." @default.
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- W2001053169 date "1990-12-15" @default.
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- W2001053169 title "Epstein–Barr virus-associated peripheral T-cell lymphoma of activated CD8 phenotype" @default.
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- W2001053169 doi "https://doi.org/10.1002/1097-0142(19901215)66:12<2557::aid-cncr2820661218>3.0.co;2-2" @default.
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