FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001057804> ?p ?o ?g. }

• W2001057804 endingPage "2556" @default.
• W2001057804 startingPage "2549" @default.
• W2001057804 abstract "Abstract The crystal structures of the haem domains of Ala330Pro and Ile401Pro, two single‐site proline variants of CYP102A1 (P450 BM3 ) from Bacillus megaterium , have been solved. In the A330P structure, the active site is constricted by the relocation of the Pro329 side chain into the substrate access channel, providing a basis for the distinctive CH bond oxidation profiles given by the variant and the enhanced activity with small molecules. I401P, which is exceptionally active towards non‐natural substrates, displays a number of structural similarities to substrate‐bound forms of the wild‐type enzyme, notably an off‐axial water ligand, a drop in the proximal loop, and the positioning of two I‐helix residues, Gly265 and His266, the reorientation of which prevents the formation of several intrahelical hydrogen bonds. Second‐generation I401P variants gave high in vitro oxidation rates with non‐natural substrates as varied as fluorene and propane, towards which the wild‐type enzyme is essentially inactive. The substrate‐free I401P haem domain had a reduction potential slightly more oxidising than the palmitate‐bound wild‐type haem domain, and a first electron transfer rate that was about 10 % faster. The electronic properties of A330P were, by contrast, similar to those of the substrate‐free wild‐type enzyme." @default.
• W2001057804 created "2016-06-24" @default.
• W2001057804 creator A5012833847 @default.
• W2001057804 creator A5017612094 @default.
• W2001057804 creator A5020504333 @default.
• W2001057804 creator A5020702515 @default.
• W2001057804 creator A5025263711 @default.
• W2001057804 creator A5027128497 @default.
• W2001057804 creator A5042039811 @default.
• W2001057804 creator A5042087506 @default.
• W2001057804 creator A5056028884 @default.
• W2001057804 creator A5070331636 @default.
• W2001057804 date "2010-11-25" @default.
• W2001057804 modified "2023-10-17" @default.
• W2001057804 title "Structural Basis for the Properties of Two Single-Site Proline Mutants of CYP102A1 (P450BM3)" @default.
• W2001057804 cites W1498652161 @default.
• W2001057804 cites W1532212858 @default.
• W2001057804 cites W1539796472 @default.
• W2001057804 cites W1559964610 @default.
• W2001057804 cites W1618585289 @default.
• W2001057804 cites W1969000829 @default.
• W2001057804 cites W1975716269 @default.
• W2001057804 cites W1976423780 @default.
• W2001057804 cites W1986191025 @default.
• W2001057804 cites W1995356653 @default.
• W2001057804 cites W1998659290 @default.
• W2001057804 cites W2000051743 @default.
• W2001057804 cites W2001641653 @default.
• W2001057804 cites W2004338840 @default.
• W2001057804 cites W2010897322 @default.
• W2001057804 cites W2015978054 @default.
• W2001057804 cites W2017843489 @default.
• W2001057804 cites W2022471249 @default.
• W2001057804 cites W2036428713 @default.
• W2001057804 cites W2038840577 @default.
• W2001057804 cites W2045081422 @default.
• W2001057804 cites W2054538965 @default.
• W2001057804 cites W2056781823 @default.
• W2001057804 cites W2061370608 @default.
• W2001057804 cites W2061474639 @default.
• W2001057804 cites W2062981552 @default.
• W2001057804 cites W2066847890 @default.
• W2001057804 cites W2067064372 @default.
• W2001057804 cites W2068925531 @default.
• W2001057804 cites W2071861224 @default.
• W2001057804 cites W2072335436 @default.
• W2001057804 cites W2072508442 @default.
• W2001057804 cites W2083979806 @default.
• W2001057804 cites W2093384465 @default.
• W2001057804 cites W2093683433 @default.
• W2001057804 cites W2097493461 @default.
• W2001057804 cites W2109569743 @default.
• W2001057804 cites W2112863694 @default.
• W2001057804 cites W2121205779 @default.
• W2001057804 cites W2122062071 @default.
• W2001057804 cites W2122919464 @default.
• W2001057804 cites W2124260805 @default.
• W2001057804 cites W2131306866 @default.
• W2001057804 cites W2132680326 @default.
• W2001057804 cites W2144081223 @default.
• W2001057804 cites W2144306433 @default.
• W2001057804 cites W2146630606 @default.
• W2001057804 cites W2152470236 @default.
• W2001057804 cites W2159150782 @default.
• W2001057804 cites W2163341755 @default.
• W2001057804 cites W2335520960 @default.
• W2001057804 cites W3213568968 @default.
• W2001057804 cites W4248144747 @default.
• W2001057804 doi "https://doi.org/10.1002/cbic.201000421" @default.
• W2001057804 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21110374" @default.
• W2001057804 hasPublicationYear "2010" @default.
• W2001057804 type Work @default.
• W2001057804 sameAs 2001057804 @default.
• W2001057804 citedByCount "62" @default.
• W2001057804 countsByYear W20010578042012 @default.
• W2001057804 countsByYear W20010578042013 @default.
• W2001057804 countsByYear W20010578042014 @default.
• W2001057804 countsByYear W20010578042015 @default.
• W2001057804 countsByYear W20010578042016 @default.
• W2001057804 countsByYear W20010578042017 @default.
• W2001057804 countsByYear W20010578042018 @default.
• W2001057804 countsByYear W20010578042019 @default.
• W2001057804 countsByYear W20010578042022 @default.
• W2001057804 countsByYear W20010578042023 @default.
• W2001057804 crossrefType "journal-article" @default.
• W2001057804 hasAuthorship W2001057804A5012833847 @default.
• W2001057804 hasAuthorship W2001057804A5017612094 @default.
• W2001057804 hasAuthorship W2001057804A5020504333 @default.
• W2001057804 hasAuthorship W2001057804A5020702515 @default.
• W2001057804 hasAuthorship W2001057804A5025263711 @default.
• W2001057804 hasAuthorship W2001057804A5027128497 @default.
• W2001057804 hasAuthorship W2001057804A5042039811 @default.
• W2001057804 hasAuthorship W2001057804A5042087506 @default.
• W2001057804 hasAuthorship W2001057804A5056028884 @default.
• W2001057804 hasAuthorship W2001057804A5070331636 @default.
• W2001057804 hasConcept C112887158 @default.
• W2001057804 hasConcept C116569031 @default.
• W2001057804 hasConcept C170493617 @default.

• next