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• W2001058831 abstract "Abstract Single fast spin echo scans covering limited time frames are mostly used for contrast‐enhanced MRI of atherosclerotic plaque biomarkers. Knowledge on inter‐scan variability of the normalized enhancement ratio of plaque (NER plaque ) and relation between NER plaque and gadolinium content for inversion‐recovery fast spin echo is limited. Study aims were: evaluation of (1) timing of MRI after intravenous injection of Cannabinoid‐2 receptor (CB2‐R) (expressed by human and mouse plaque macrophages) targeted micelles; (2) inter‐scan variability of inversion‐recovery fast spin echo and fast spin echo; (3) relation between NER plaque and gadolinium content for inversion‐recovery fast spin echo and fast spin echo. Inversion‐recovery fast spin echo/fast spin echo imaging was performed before and every 15 min up to 48 h after injection of CB2‐R targeted or control micelles using several groups of mice measured in an interleaved fashion. NER plaque (determined on inversion‐recovery fast spin echo images) remained high (∼2) until 48 h after injection of CB2‐R targeted micelles, whereas NER plaque decreased after 36 h in the control group. The inter‐scan variability and relation between NER plaque and gadolinium (assessed with inductively coupled plasma‐ mass spectrometry) were compared between inversion‐recovery fast spin echo and fast spin echo. Inter‐scan variability was higher for inversion‐recovery fast spin echo than for fast spin echo. Although gadolinium and NER plaque correlated well for both techniques, the NER of plaque was higher for inversion‐recovery fast spin echo than for fast spin echo. In mice injected with CB2‐R targeted micelles, NER plaque can be best evaluated at 36–48 h post‐injection. Because NER plaque was higher for inversion‐recovery fast spin echo than for fast spin echo, but with high inter‐scan variability, repeated inversion‐recovery fast spin echo imaging and averaging of the obtained NER plaque values is recommended. Copyright © 2010 John Wiley & Sons, Ltd." @default.
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• W2001058831 date "2010-06-03" @default.
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• W2001058831 title "The time window of MRI of murine atherosclerotic plaques after administration of CB2 receptor targeted micelles: inter-scan variability and relation between plaque signal intensity increase and gadolinium content of inversion recovery prepared versus non-" @default.
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• W2001058831 doi "https://doi.org/10.1002/nbm.1514" @default.
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