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- W2001061126 endingPage "1038" @default.
- W2001061126 startingPage "1026" @default.
- W2001061126 abstract "The benefit of postoperative adjuvant chemotherapy in patients with Dukes' B colorectal cancer is still uncertain and its routine use is not recommended. Prognostic biomarkers may be useful for identifying high-risk patients with resected, node-negative disease, and this stratification may represent an innovative strategy for designing adjuvant chemotherapy trials. Featured prognostic molecular markers can be divided into the following categories: cell proliferation indices (Ki-67, Mib-1, proliferating cell nuclear antigen); oncogenes/tumor suppressor genes [p53, K-ras, Deleted in Colorectal Cancer (DCC), Bcl-2, c-erbB2]; DNA repair (microsatellite instability); markers of angiogenesis (vascular count, vascular endothelial growth factor); markers of invasion/metastasis (plasminogen-related molecules, matrix metalloproteinases); and biochemical markers (thymidylate synthase). Studies that have investigated their prognostic role in Dukes' B colorectal cancer patients are reviewed here. Current data do not provide sufficient evidence for the incorporation of available prognostic biomarkers into clinical practice. However, a biomarker-based approach could be an effective strategy for improving results of postoperative adjuvant treatments in high-risk Dukes' B colorectal cancer patients. Markers of altered DCC function have shown promising prognostic role and sufficient prevalence in retrospective investigations and they deserve further assessment in prospective studies." @default.
- W2001061126 created "2016-06-24" @default.
- W2001061126 creator A5018141422 @default.
- W2001061126 creator A5042028913 @default.
- W2001061126 date "2003-07-01" @default.
- W2001061126 modified "2023-09-27" @default.
- W2001061126 title "Prognostic molecular markers for planning adjuvant chemotherapy trials in Dukes’ B colorectal cancer patients: how much evidence is enough?" @default.
- W2001061126 cites W1483996159 @default.
- W2001061126 cites W1545777866 @default.
- W2001061126 cites W1853602163 @default.
- W2001061126 cites W1880053619 @default.
- W2001061126 cites W1884213330 @default.
- W2001061126 cites W1935492807 @default.
- W2001061126 cites W1965116477 @default.
- W2001061126 cites W1965267495 @default.
- W2001061126 cites W1965327752 @default.
- W2001061126 cites W1967007810 @default.
- W2001061126 cites W1969026343 @default.
- W2001061126 cites W1976738458 @default.
- W2001061126 cites W1976963261 @default.
- W2001061126 cites W1982410615 @default.
- W2001061126 cites W1986048463 @default.
- W2001061126 cites W1986388027 @default.
- W2001061126 cites W1986937402 @default.
- W2001061126 cites W1989305101 @default.
- W2001061126 cites W1990105318 @default.
- W2001061126 cites W1995819860 @default.
- W2001061126 cites W1996449685 @default.
- W2001061126 cites W1997201791 @default.
- W2001061126 cites W1997437779 @default.
- W2001061126 cites W1999284067 @default.
- W2001061126 cites W2001503989 @default.
- W2001061126 cites W2006924771 @default.
- W2001061126 cites W2018009295 @default.
- W2001061126 cites W2018642772 @default.
- W2001061126 cites W2021222669 @default.
- W2001061126 cites W2021948632 @default.
- W2001061126 cites W2022281814 @default.
- W2001061126 cites W2025425767 @default.
- W2001061126 cites W2025622002 @default.
- W2001061126 cites W2025763214 @default.
- W2001061126 cites W2032930680 @default.
- W2001061126 cites W2034582254 @default.
- W2001061126 cites W2037698244 @default.
- W2001061126 cites W2037775391 @default.
- W2001061126 cites W2038771130 @default.
- W2001061126 cites W2040160664 @default.
- W2001061126 cites W2040178251 @default.
- W2001061126 cites W2041754734 @default.
- W2001061126 cites W2042245721 @default.
- W2001061126 cites W2043571618 @default.
- W2001061126 cites W2045578382 @default.
- W2001061126 cites W2045872129 @default.
- W2001061126 cites W2045919115 @default.
- W2001061126 cites W2047057598 @default.
- W2001061126 cites W2048077054 @default.
- W2001061126 cites W2048941208 @default.
- W2001061126 cites W2049852228 @default.
- W2001061126 cites W2049872933 @default.
- W2001061126 cites W2051738969 @default.
- W2001061126 cites W2053627694 @default.
- W2001061126 cites W2057078243 @default.
- W2001061126 cites W2057965634 @default.
- W2001061126 cites W2061159071 @default.
- W2001061126 cites W2065031458 @default.
- W2001061126 cites W2065161914 @default.
- W2001061126 cites W2065942363 @default.
- W2001061126 cites W2071426621 @default.
- W2001061126 cites W2074336818 @default.
- W2001061126 cites W2074381728 @default.
- W2001061126 cites W2078763660 @default.
- W2001061126 cites W2082026751 @default.
- W2001061126 cites W2086101934 @default.
- W2001061126 cites W2088098884 @default.
- W2001061126 cites W2088377055 @default.
- W2001061126 cites W2094782898 @default.
- W2001061126 cites W2099753233 @default.
- W2001061126 cites W2101333644 @default.
- W2001061126 cites W2103942628 @default.
- W2001061126 cites W2114149902 @default.
- W2001061126 cites W2117849323 @default.
- W2001061126 cites W2120339030 @default.
- W2001061126 cites W2122945783 @default.
- W2001061126 cites W2123611321 @default.
- W2001061126 cites W2124924645 @default.
- W2001061126 cites W2127330908 @default.
- W2001061126 cites W2128888929 @default.
- W2001061126 cites W2130042515 @default.
- W2001061126 cites W2132805485 @default.
- W2001061126 cites W2132979902 @default.
- W2001061126 cites W2136096177 @default.
- W2001061126 cites W2136509556 @default.
- W2001061126 cites W2146215003 @default.
- W2001061126 cites W2148296009 @default.
- W2001061126 cites W2153525480 @default.
- W2001061126 cites W2154648888 @default.
- W2001061126 cites W2165496831 @default.
- W2001061126 cites W2165976417 @default.