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- W2001064341 abstract "As the number of patients with congenital heart defects requiring heart valve replacement increases, the need for durable valve substitutes with good hemodynamic performance and a low incidence of complications becomes more apparent. The use of porcine xenografts is burdened with early fibrocalcific degeneration, whereas the use of mechanical heart valves led to an increased number of thromboembolic events, especially when implanted in the right side of the heart. We report on our experiences implanting bileaflet heart valves in congenital heart defects since the introduction of international normalized ratio (INR) self-management. The data of 68 long-term survivors (33 males, 35 females) who underwent mechanical heart valve replacement in congenital heart defect were reviewed. Patient age at the time of valve replacement ranged from 5 months to 61 years (mean 21 years). Underlying diagnoses were tetralogy of Fallot (n = 33), morbus Ebstein (n = 4), atrioventricular canal (n = 13), truncus arteriosus communis (n = 5), transposition of the great arteries (n = 10), and congenitally corrected transposition of the great arteries (n = 3). In all patients, bileaflet valves were implanted (St. Jude Medical n = 40, Carbomedics n = 28). Anticoagulation was performed using dicumarol (Marcumar) and INR self-management in all cases. The mean follow-up was 72 months (range 6–132 months; 409 patient-years). Valve thrombosis developed in 3 of 68 patients (4.4%, all three had tetralogy of Fallot, mean age 9.8 years) after a mean follow-up of 3.5 years. In two of these three patients, re-pulmonary valve replacement was necessary, whereas the third patient was treated by thrombolysis. From our experience, we conclude that mechanical heart valve replacement is a good therapy option with a low complication rate for patients with congenital heart defects requiring valve replacement, especially when INR self-management is performed." @default.
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- W2001064341 date "2005-09-01" @default.
- W2001064341 modified "2023-10-17" @default.
- W2001064341 title "Mechanical Valve Replacement in Congenital Heart Defects in the Era of International Normalized Ratio Self-Management" @default.
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- W2001064341 doi "https://doi.org/10.1097/01.mat.0000176119.56534.90" @default.
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