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- W2001065306 abstract "Platelets play an important role in the pathogenesis of acute myocardial infarction and unstable angina. However, it is still unclear if platelets become activated only upon atherosclerotic plaque rupture, or if platelet activation precedes this event and contributes to atherosclerosis itself. Some studies suggest that platelet activation occurs in patients with coronary artery disease (CAD). It is known that patients with multiple stents have a higher rate of restenosis, however, the mechanism of this association is not understood. Patients with stable CAD have been shown to exhibit increased platelet surface P-selectin and enhanced platelet aggregation in response to adenosine diphosphate (ADP), epinephrine, and thrombin receptor agonist peptide [ [1] Furman MI Benoit SE Barnard MR Valeri CR Borbonne ML Becker RC Hechtman HB Michelson AD Increased platelet reactivity and circulating monocyte–platelet aggregates in patients with stable coronary artery disease. J Am Coll Cardiol. 1998; 31: 352-358 Abstract Full Text Full Text PDF PubMed Scopus (462) Google Scholar ]. Platelet surface P-selectin and platelet–leukocyte adhesion are also increased in patients with symptomatic CAD [ [2] Gawaz M Reininger A Neumann FJ Platelet function and platelet–leukocyte adhesion in symptomatic coronary heart disease. Effects of intravenous magnesium. Thromb Res. 1996; 83: 341-349 Abstract Full Text Full Text PDF PubMed Scopus (55) Google Scholar ]. Platelet factor 4 and fibronectin plasma levels are also high in such patients [ [3] Ulutin T Sonmez H Ucisik N Suer S Bayram C Kokoglu E Sultuybek G The molecular markers of hemostatic activation on coronary artery disease. Thromb Res. 1997; 88: 329-332 Abstract Full Text Full Text PDF PubMed Scopus (10) Google Scholar ]. Platelet surface receptors, namely GP53, GP IIb/IIIa, P-selectin, and CD63 are increased in patients with severe CAD [ 4 Cahill MR Macey MG Dawson JR Newland AC Platelet surface activation antigen expression at baseline and during elective angioplasty in patients with mild to moderate coronary artery disease. Blood Coagulation Fibrinolysis. 1996; 7: 165-168 Crossref PubMed Scopus (16) Google Scholar , 5 Murakami T Komiyama Y Masuda M Kido H Nomura S Fukuhara S Karakawa M Iwasaka T Takahashi H Flow cytometric analysis of platelet activation markers CD62P and CD63 in patients with coronary artery disease. Eur J Clin Invest. 1996; 26: 996-1003 Crossref PubMed Scopus (57) Google Scholar ]." @default.
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- W2001065306 date "2001-01-01" @default.
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- W2001065306 title "Platelet Function and Total Length of Intracoronary Stents: Is There a Correlation?" @default.
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- W2001065306 doi "https://doi.org/10.1016/s0049-3848(00)00372-8" @default.
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