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- W2001066955 abstract "872 www.thelancet.com Vol 376 September 11, 2010 Authors’ reply We thank Manoj Kumar for his thoughtful observations. We acknowledged that the limitation of our approach was the lack of good quality mortality data. We elected to present upper and lower bounds rather than a point estimate to refl ect the uncertainty while still judging this to be worthwhile as the fi rst attempt to quantify the global mortality from acute lower respiratory infections associated with respiratory syncytial virus (RSV). Kumar suggests that by excluding the seven studies with a case fatality ratio (CFR) of zero, we might have overestimated the lower bound. The studies were reviewed in detail and the reasons for exclusion are sum marised in the webappendix. From this analysis, we judged each to be ineligible on methodological grounds: inadequate sample size, lack of referral of severely ill children, or bias due to a failure to study the most severely ill children. Inclusion of studies with very small sample sizes would inevitably have biased downwards the median estimates Childhood mortality due to respiratory syncytial virus" @default.
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- W2001066955 date "2010-09-01" @default.
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- W2001066955 title "Childhood mortality due to respiratory syncytial virus – Authors' reply" @default.
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- W2001066955 doi "https://doi.org/10.1016/s0140-6736(10)61410-9" @default.
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