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- W2001068822 abstract "Abstract A ribosome-supernatant system capable of active amino acid incorporation into protein in vitro was prepared from rat uterus. Requirements and properties of this system do not differ markedly from those of similar preparations from other rat tissues. Manipulation of estrogen levels in vivo primarily affected the ribosome component of the system. Following ovariectomy, the incorporating activity of the ribosomes at 1 day was transiently lowered but was restored to normal in the second and subsequent days. The lowered activity of ribosomes was associated with an increased response to addition of polyuridylic acid, whereas a short (4 hours before killing) treatment with estrogen increased ribosomal activity while decreasing the response to the synthetic messenger. The yield of ribosomes obtained in a standard fractionation dropped sharply after ovariectomy, and was restored by a short-term treatment with estrogen. The results are interpreted as indicating that both the number and the capacity of the ribosomes are estrogen-dependent." @default.
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- W2001068822 date "1964-07-01" @default.
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- W2001068822 title "Effects of alterations in hormonal status on ribosomes of rat uterus" @default.
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- W2001068822 doi "https://doi.org/10.1016/0003-9861(64)90261-9" @default.
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