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• W2001069342 abstract "The analgesic properties of the catecholamine uptake inhibitor nomifensine were investigated in the tail immersion, hot plate and formalin tests. Systemic administration of nomifensine produced analgesia only in the formalin test. The analgesia was dose-dependent (0.625-5 mg/kg), and the highest dose completely abolished nociceptive behaviors induced by 2% formalin. The analgesia was not affected by the opioid antagonist naltrexone (2.5-40 microg s.c.) but was dose-dependently reversed by the D2 antagonist eticlopride (181.3-270 microg/kg i.p.). Neither naltrexone nor eticlopride affected formalin pain scores. Nomifensine analgesia appears to be dopamine-mediated but independent of opioid mechanisms." @default.
• W2001069342 created "2016-06-24" @default.
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• W2001069342 date "2001-04-01" @default.
• W2001069342 modified "2023-09-28" @default.
• W2001069342 title "Characterization of the analgesic properties of nomifensine in rats" @default.
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• W2001069342 doi "https://doi.org/10.1016/s0091-3057(01)00479-8" @default.
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